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Diabetes patients with low osteocalcin levels at increased risk of mortality: BMC

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-06-20T11:00:47+05:30  |  Updated On 20 Jun 2022 3:57 PM IST
Diabetes patients with low osteocalcin levels at increased risk of mortality: BMC
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China: A new study published in Cardiovascular Diabetology shows that in type 2 diabetes patients, there was a relationship between baseline osteocalcin and death. Patients with lower serum osteocalcin during follow-ups were found to have a higher risk for all-cause and cardiovascular mortality.

The relationship between osteocalcin and mortality has received little attention. As a result, Yun Shen and colleagues designed this study to look at the relationship between osteocalcin, its trajectories, and mortality using long-term longitudinal data.

A retrospective cohort analysis of 9413 type 2 diabetic patients having at least three total blood osteocalcin readings within three years of their first hospital diagnosis of type 2 diabetes was done. As exposures, baseline, mean osteocalcin levels, and their trajectories were employed. The relationship between osteocalcin levels and their trajectories with death was estimated using a multivariable-adjusted Cox proportional hazards model.

The key findings of this study were as follows:

1. During a 5.37-year average follow-up, 1638 patients died, 588 of them died as a result of cardiovascular events.

2. The multivariable-adjusted hazard ratios (HRs) for all-cause mortality were 2.88, 1.65, 1.17, 1.00, and 1.92, respectively, and 3.52, 2.00, 1.03, 1.00, and 1.67 for cardiovascular disease (CVD) mortality.

3. Researchers discovered U-shaped relationships when they utilized the mean values of osteocalcin as the exposure.

4. These U-shaped relationships were seen in patients with a variety of baseline characteristics.

5. Patients with a steady or even growing osteocalcin trajectory may have a decreased risk of all-cause and CVD death.

In conclusion, the study, which used data from the Shanghai Clinical Center for Diabetes, discovered a U-shaped relationship between blood osteocalcin levels and the chances of all-cause and CVD mortality in type 2 diabetes patients. Secondary trajectory analyses confirmed that individuals with lower blood osteocalcin levels had a greater risk of all-cause and CVD death. Further interventional studies to target the therapy impact of osteocalcin are difficult to conduct.

Reference:

Shen, Y., Chen, L., Zhou, J., Wang, C., Gao, F., Zhu, W., Hu, G., Ma, X., Xia, H., & Bao, Y. (2022). Low total osteocalcin levels are associated with all-cause and cardiovascular mortality among patients with type 2 diabetes: a real-world study. In Cardiovascular Diabetology (Vol. 21, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12933-022-01539-z

type 2 diabetesosteocalcinCardiovascular Diabetology
Source : Cardiovascular Diabetology
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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