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  • HbA1c useful for...

HbA1c useful for identifying women at risk for pregnancy complications: Study

MedhaBy MedhaPublished On 2021-12-25T09:00:41+05:30  |  Updated On 2021-12-25T09:00:48+05:30
HbA1c useful for identifying women at risk for pregnancy complications: Study

France: Glycated haemoglobin (HbA1c) at gestational diabetes diagnosis may identify women at risk for pregnancy complications, reveals a recent study. Findings of the study, published in the journal Diabetes & Metabolism, suggest that HbA1c at the time of testing for gestational diabetes may be a useful pragmatic tool for identifying women at risk. This would be helpful for...

France: Glycated haemoglobin (HbA1c) at gestational diabetes diagnosis may identify women at risk for pregnancy complications, reveals a recent study. 

Findings of the study, published in the journal Diabetes & Metabolism, suggest that HbA1c at the time of testing for gestational diabetes may be a useful pragmatic tool for identifying women at risk. This would be helpful for identifying and applying preventative treatment for women at increased risk. 

Prior to the study it was not clear whether HbA1c has utility in predicting adverse outcomes in GDM. Anne Vambergue, University of Lille, Lille, France, and the team therefore aimed to examine the predictive value of HbA1c at GDM diagnosis with adverse pregnancy outcomes in a cohort study.

The study included 4,383 women with GDM between 2011 and 2018. The association of HbA1c with pregnancy outcomes were assessed before and after adjustment for predefined risk factors of GDM. The researchers examined these association considering HbA1c as categorical variables using five pre-specified HbA1c classes: and as a continuous variable. 

Based on the study, the researchers found the following:

  • An HbA1c ≥ 5.6% (38 mmol/mol) identified women with at greater risk for macrosomia: odds ratio (OR) = 2.12 for HbA1c = 5.6-5.9% and 2.06 for HbA1c > 5.9% versus HbA1c ≤ 4.5% (26 mmol/mol).
  • HbA1c ≥ 5.6% (38 mmol/mol) was associated with greater risk for caesarean: 1.64 for HbA1c = 5.6-5.9% and 1.58 for HbA1c > 5.9% (41 mmol/mol) versus HbA1c ≤ 4.5% (26 mmol/mol).
  • Using HbA1c ≤ 4.5% (26 mmol/mol) as reference category, HbA1c > 5.9% (41 mmol/mol) increased the OR of preterm delivery to 3.33.
  • HbA1c remained significant for Adverse Pregnancy Outcome Composite after adjustment.

"The findings suggest that a single HbA1c reading may be a useful pragmatic tool to identify women at risk," wrote the authors. "Such identification may be a useful guide for identifying and applying preventative treatment for women at increased risk."

Reference:

The study titled, "HbA1c at the time of testing for gestational diabetes identifies women at risk for pregnancy complications," was published in the journal Diabetes & Metabolism. 

DOI: https://doi.org/10.1016/j.diabet.2021.101313

Diabetes & Metabolism gestational diabetes pregnancy complications HbA1c 
Source : Diabetes & Metabolism
Medha
Medha

    Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751

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