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  • Higher HbA1c levels...

Higher HbA1c levels and longer duration of Diabetes increase HF risk among Diabetics

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-11-30T09:00:50+05:30  |  Updated On 30 Nov 2022 2:08 PM IST
Higher HbA1c levels and longer duration of Diabetes increase HF risk among Diabetics
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New research found that there is an increased risk of heart failure among diabetic patients who have had diabetes for a long duration and increased HbA1c levels. The study results were published in The Journal of Clinical Endocrinology and Metabolism.

Diabetes is a global pandemic and there is an increased risk of cardiorenal problems in patients with diabetes. Diabetes duration and glycemic control have a potential role in the risk of heart failure (HF) in diabetics but there is uncertainty over the same. Hence researchers conducted a study to investigate the association of diabetes duration and glycemic control with the risk of HF.

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Nearly 23,754 individuals with diabetes but without HF during the baseline recruitment of UK Biobank were recruited for the study. All the participants self-reported the duration of diabetes, and the status of glycemic control was reflected by glycated hemoglobin A1c (HbA1c) levels. The association of diabetes duration and glycemic control with incident HF was assessed using multivariate Cox models adjusting for traditional risk factors.

Results:

Duration of diabetes and HbA1c levels both were positively associated with the risk of HF.

The hazard ratios (HRs) (95% CI) for diabetes durations (vs < 5 years); and the HRs for HbA1c (vs < 53.0 mmol/mol [7.0%]) are as follows.

Diabetes Duration Hazard ratios (95% CI)

5 -10 years

1.09 (0.97-1.23)

10-15 years

1.13 (0.97-1.30)

15 and more years

1.32 (1.15-1.53)

HbA1c
53-58.5 mmol/mol (7.0% to < 7.5%)

1.15 (1.02-1.31)

58.5 - 63.9 mmol/mol (7.5% to < 8.0%)

1.07 (0.91-1.26)

63.9 mmol/mol or greater (8.0%)

1.46 (1.30-1.65)

A higher risk of HF (P for interaction = .026) was found especially in Individuals with the longest disease duration (≥ 15 years) and poorer glycemic control (HbA1c ≥ 63.9 mmol/mol [8.0%]).

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Thus, the study finds that there is an increased risk of heart failure in diabetic patients with an increased duration of diabetes and increased HBA1c levels.

Further reading: Yang HH, Li FR, Chen ZK, et al. Duration of Diabetes, Glycemic Control, and Risk of Heart Failure Among Adults With Diabetes: A Cohort Study [published online ahead of print, 2022 Nov 16]. J Clin Endocrinol Metab. 2022;dgac642. doi: 10.1210/clinem/dgac642

diabetesglycated hemoglobinglycemic controlheart failurediabetes durationHbA1cindividualized prevention
Source : The Journal of Clinical Endocrinology and Metabolism
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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