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  • Insulin detemir has...

Insulin detemir has similar neonatal mortality risk as other basal insulins in pregnant diabetics: Study

Medha BaranwalWritten by Medha Baranwal Published On 2021-08-17T09:00:59+05:30  |  Updated On 2021-08-17T09:01:08+05:30
Insulin detemir has similar neonatal mortality risk as other basal insulins in pregnant diabetics: Study

Delhi: Treatment with insulin detemir versus other basal insulins in pregnant women with preexisting diabetes is associated with a similar risk of major congenital malformations and neonatal mortality, show results from a recent prospective study. The study findings appear in the journal Diabetes Care.Elisabeth R. Mathiesen, Center for Pregnant Women with Diabetes, Rigshospitalet,...

Delhi: Treatment with insulin detemir versus other basal insulins in pregnant women with preexisting diabetes is associated with a similar risk of major congenital malformations and neonatal mortality, show results from a recent prospective study. The study findings appear in the journal Diabetes Care.

Elisabeth R. Mathiesen, Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark, and colleagues aimed to compare the risk of severe adverse pregnancy complications in women with preexisting diabetes.

For this purpose, they conducted a multinational, prospective cohort study to assess the prevalence of newborns free from major congenital malformations or perinatal or neonatal death (primary endpoint) after treatment with insulin detemir (detemir) versus other basal insulins.

The study included a total of 1,457 women, out of which 727 received detemir and 730 received other basal insulins. 

Upon analysis, the researchers found the following:

  • The prevalence of newborns free from major congenital malformations or perinatal or neonatal death was similar between detemir (97.0%) and other basal insulins (95.5%) (crude risk difference 0.015; adjusted risk difference −0.003).
  • The crude prevalence of one or more congenital malformations (major plus minor) was 9.4% vs. 12.6%, with a similar risk difference before (−0.032) and after (−0.036) adjustment for confounders.
  • Crude data showed lower maternal HbA1c during the first trimester (6.5% vs. 6.7% [48 vs. 50 mmol/mol]) and the second trimester (6.1% vs. 6.3% [43 vs. 45 mmol/mol]) and a lower prevalence of major hypoglycemia (6.0% vs. 9.0%), preeclampsia (6.4% vs. 10.0%), and stillbirth (0.4% vs. 1.8%) with detemir compared with other basal insulins. However, differences were not significant post adjustment.

The findings showed that insulin detemir was associated with a similar risk to other basal insulins of major congenital malformations, perinatal or neonatal death, hypoglycemia, preeclampsia, and stillbirth, concluded the authors. 

Reference:

The study titled, "Risk of Major Congenital Malformations or Perinatal or Neonatal Death With Insulin Detemir Versus Other Basal Insulins in Pregnant Women With Preexisting Diabetes: The Real-World EVOLVE Study," is published in the journal Diabetes Care. 

DOI: https://care.diabetesjournals.org/content/early/2021/07/30/dc21-0472

Diabetes Care insulin detemir neonatal mortality pregnancy Diabetes in pregnancy 
Source : Diabetes Care
Medha Baranwal
Medha Baranwal

    Medha, MSc. Biotechnology

    Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751

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