One-Hour OGTT as accurate as two hr OGTT for diabetes detection, finds study
USA: A 1-hour oral glucose tolerance test (OGTT) is equally effective as a 2-hr OGTT for the prediction of type 1 diabetes (T1D) with minimal risk of missing a T1D diagnosis before the next visit, suggests a recent study in the Journal of Clinical Endocrinology & Metabolism. The findings will do away with the need to perform time-consuming and costly 2-hour OGTTs.After the identification...
USA: A 1-hour oral glucose tolerance test (OGTT) is equally effective as a 2-hr OGTT for the prediction of type 1 diabetes (T1D) with minimal risk of missing a T1D diagnosis before the next visit, suggests a recent study in the Journal of Clinical Endocrinology & Metabolism. The findings will do away with the need to perform time-consuming and costly 2-hour OGTTs.
After the identification of islet autoantibody-positive individuals, it becomes important to predict the patients at the highest risk of T1D. A metabolic risk score obtained from 2-hr OGTT data, the Diabetes Prevention Trial-Type 1 risk score (DPTRS) can help in the accurate prediction of T1D.
Kimber M Simmons, University of Colorado School of Medicine, Aurora, CO, and colleagues aimed to determine whether a risk score derived from 1-hour OGTT data can predict T1D as accurately as the Diabetes Prevention Trial-Type 1 risk score (DPTRS). Secondarily, they evaluated whether a 1-hour glucose value can be used for diagnostic surveillance.
The researchers modified the DPTRS to derive a 1-hour OGTT risk score (DPTRS60) through the use of 1-hour glucose and C-peptide, dating C-peptide, age, and BMI. Prediction accuracies of DPTRS60 with DPTRS in Diabetes Prevention Trial-Type 1 (DPT-1) (n=654) and TrialNet Pathway to Prevention (TNPTP) (n=4610) participants were determined through the use of areas under receiver operating curves (ROCAUC). Negative predictive values (NPV) for T1D diagnosis were derived for 1-hour glucose thresholds.
Key findings of the study include:
- ROCAUC for T1D prediction 5 years from baseline was similar between DPTRS60 vs. DPTRS (DPT-1: 0.805 and 0.794; TNPTP: 0.832 and 0.847, respectively).
- DPTRS60 predicted T1D significantly better than 2-hour glucose.
- A 1-hour glucose &180 mg/dl had a similar NPV, PPV and specificity for T1D development before the next 6-month visit as the standard 2-hour threshold &140 mg/dl (both ≥98.5%).
"1-hour and 2-hour oral GTTs show similar accuracy in predicting T1D," concluded the authors.
The study, "One-Hour Oral Glucose Tolerance Tests for the Prediction and Diagnostic Surveillance of Type 1 Diabetes," is published in the Journal of Clinical Endocrinology & Metabolism.
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at firstname.lastname@example.org. Contact no. 011-43720751