Triglyceride glucose index superior to HOMA-IR for predicting type 2 diabetes: Study
Korea: A recent study in the journal Diabetes Research and Clinical Practice has shown the triglyceride-glucose (TyG) index to be superior to HOMA-IR for the prediction of type 2 diabetes. The findings imply that the TyG index may be a useful tool for the prevention and detection of T2D.
Previous studies have shown insulin resistance to be an independent risk factor for the development of type 2 diabetes. Jun-Hyuk Lee, Eulji University School of Medicine, Seoul, Republic of Korea, and colleagues aimed to compare the predictability of the triglyceride–glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) for the prevalence and incidence of type 2 diabetes.
For this purpose, the researchers analyzed data from 9730 adults aged 40–69 years at baseline and 7783 participants without diabetes. They were followed up in the Korean Genome and Epidemiology Study survey. This survey was conducted biennially (six follow-ups) from
We analyzed data from 9730 adults aged 40–69 years at baseline and 7783 participants without diabetes who were followed up in the Korean Genome and Epidemiology Study survey. From 2001 to 2002 (baseline survey) to 2013–2014, this survey was conducted biennially (six follow-ups). The average follow-up period was 9.0 years.
Key findings include:
- The TyG index showed better predictability for the prevalence of type 2 diabetes than HOMA-IR (TyG index: 0.784, HOMA-IR: 0.728).
- The area under the time-dependent receiver operating characteristic curve of the TyG index for incident type 2 diabetes was 0.640, which was significantly higher than that of HOMA-IR [0.531].
The researchers concluded, "The triglyceride–glucose (TyG) index is superior to HOMA-IR for predicting type 2 diabetes. The TyG index could, therefore, be more useful for the early detection and prevention of type 2 diabetes."
Reference:
The study titled, "The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance," is published in the journal Diabetes Research and Clinical Practice.
DOI: https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(21)00401-0/fulltext
