Urinary endocrine-disrupting chemicals do not increase risk of metabolic syndrome among women

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-12-19T04:30:06+05:30 | Updated On 19 Dec 2023 1:01 PM IST

A recent multiethnic study highlighted the potential connection between exposure to certain environmental chemicals and the prevalence of metabolic syndrome (MetS) in women. The findings of the study were published in the Journal of the Endocrine Society.

Metabolic syndrome is a group of conditions associated with an elevated risk of cardiovascular disease, includes factors like high blood pressure, elevated fasting glucose, increased triglycerides, expanded waist circumference, and low levels of high-density lipoprotein cholesterol.

This analysis focused on four classes of urinary endocrine-disrupting chemicals (EDCs), the bisphenol A (BPA), triclosan, parabens, and phthalates. The study involved 1728 women after adjusting for variables such as age, body mass index (BMI), racial and ethnic background, and breast cancer status.

The results showed that metabolic syndrome was identified in 30.0% of the women. There were no statistically significant associations between MetS and BPA, triclosan, or phthalate metabolite excretion. Also, an intriguing inverse relationship emerged with total parabens (Ptrend = .002) was noticed which indicated a potential protective effect against metabolic syndrome.

The study explored potential variations in these associations based on race, ethnicity, and BMI. While these were suggestive of inverse associations between EDCs and MetS among Latino and African American women, no statistically significant heterogeneity was detected in those with a BMI under 30 kg/m2.

The findings of this study suggest a complex interplay between environmental exposures and metabolic health, particularly among women. This inverse association observed here with parabens prompts further investigation into the potential protective role of these chemicals in the context of MetS.

Reference:

Ihenacho, U., Guillermo, C., Wilkens, L. R., Franke, A. A., Tseng, C., Li, Y., Sangaramoorthy, M., Derouen, M. C., Haiman, C. A., Stram, D. O., Le Marchand, L., Cheng, I., & Wu, A. H. (2023). Association of endocrine disrupting chemicals with the Metabolic syndrome among women in the Multiethnic Cohort Study. Journal of the Endocrine Society, 7(12). https://doi.org/10.1210/jendso/bvad136

Journal of the Endocrine SocietyParabenBisphenol-A (BPA)Metabolic syndrome

Source : Journal of the Endocrine Society

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751