- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Germinated brown rice may benefit diabetes patients through catabolism of branched-chain amino acids
China: Germinated brown rice (GBR) intervention in type 2 diabetes mellitus (T2DM) patients was associated with improved biochemical indicators, researchers state in a study published in Molecular Nutrition & Food Research. The underlying mechanism of GBR could be an improvement in insulin resistance and acceleration of BCAAs (branched-chain amino acids) catabolism.
In the GBR group (patients receiving GBR intervention), the study showed a decrease in fasting blood glucose, fasting insulin, and serum BCAAs, and an improvement in islet function.
Adequate consumption of whole grain foods benefits patients with type 2 diabetes. However, there is no clarity on whether preventive effects are related to BCAAs metabolism. Yujuan Shan from Wenzhou Medical University in Wenzhou, Zhejiang, China, and colleagues aimed to assess the impact of GBR intervention on the metabolism of branched-chain amino acids in type 2 diabetes patients in a randomized controlled trial.
Participants with T2DM were randomized to 100 g/d GBR (GBR group, n = 42) or equal staple food (Control group, n = 25) for three months. The researchers collected serum samples and food frequency questionnaires (FFQ) before and after the intervention.
The authors reported the following findings:
- In the GBR group, fasting insulin (FINS), fasting blood glucose (FBG), and serum BCAAs were decreased, and islet function was improved.
- Logistic regression analysis showed that FBG (Odds ratios (OR): 1.55) and energy (OR: 1.21) were positively associated with serum total BCAAs level, while FINS was negatively associated (OR: 0.20).
- There was a significant increase in the key enzymes of BCAAs decomposition, which promoted glycolysis by activating pyruvate dehydrogenase (PDH).
The authors conclude, "germinated brown rice could improve biochemical indicators of type 2 diabetes patients, and the underlying mechanism may be through improvement in insulin resistance and accelerating catabolism of BCAAs."
Reference:
Wan W, Jiang X, Zhao R, Cai F, Wu F, Hu Y, Zhou X, Liu Z, Shan Y. Branched Chain Amino Acids, New Target of Germinated Brown Rice against Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Mol Nutr Food Res. 2022 Dec 23:e2200481. doi: 10.1002/mnfr.202200481. Epub ahead of print. PMID: 36564930.
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751