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Chronic opioid use may be risk factor for certain esophageal dysmotility disorders
![Chronic opioid use may be risk factor for certain esophageal dysmotility disorders Chronic opioid use may be risk factor for certain esophageal dysmotility disorders](https://medicaldialogues.in/h-upload/2023/08/01/750x450_215532-untitled-design-2023-08-01t205629749.webp)
Chronic opioid usage is a risk factor for certain esophageal dysmotility disorders, mentions a review article "Systematic review with meta-analysis: Chronic opioid use is associated with esophageal dysmotility in symptomatic patients" by Niu et al. and colleagues.
This study is published in The American Journal of Gastroenterology.
In this study, researchers did a systematic review and meta-analysis to assess the impact of chronic opioid exposure on esophageal motility in patients undergoing manometric evaluation. For this study, Multiple databases were searched for relevant patients using opioids for over 90 days.
Esophageal dysmotility disorders were the primary outcomes measured, while the secondary outcomes were Three high-resolution manometry parameters.
The study results are:
- The analysis had nine studies.
- Opioid usage was tied to higher esophageal dysmotility disorders, including distal esophageal spasm, esophagogastric junction outflow obstruction and type III achalasia.
- There were no significant differences for hypercontractile esophagus, type I achalasia, or type II achalasia.
- Researchers found basal lower esophageal sphincter pressure, integrated relaxation pressure and distal contractile integral to be significantly different between the opioid use and nonopioid use group.
- Opioid use was related to the lower risk of ineffective esophageal motility.
They said, “We found that Chronic opioid exposure increases the frequency of esophageal dysmotility disorders. Based on the results of our study, opioid use is related to Type III achalasia and not Type I and II achalasia.”
Further reading:
https://journals.lww.com/ajg/Abstract/9900/Systematic_review_with_meta_analysis__Chronic.817.aspx
BDS, MDS in Periodontics and Implantology
Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751