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Split-dose oral sulfate solution regimen as effective as split-dose 3-liter polyethylene glycol regimen for preparing bowel for colonoscopy
Split-dose oral sulfate solution regimen as effective as split-dose 3-liter polyethylene glycol regimen for preparing bowel for colonoscopy suggests anew study published in the Gastrointestinal Endoscopy
Adequate bowel preparation is crucial for clear mucosal visualization during colonoscopy. Researchers aimed to comprehensively compared oral sulfate solution (OSS) and 3-liter split-dose Polyethylene glycol (PEG) for bowel preparation before colonoscopy.
This randomized, active-controlled, noninferiority study was performed in ten medical centers. The eligible subjects were enrolled to receive OSS or 3-liter PEG in a split-dose regimen. The quality of bowel preparation, adverse reactions, and acceptability were evaluated. The quality of bowel preparation was evaluated using the Boston Bowel Preparation Scale (BBPS). Safety was evaluated by adverse reactions. The study population was divided into the full analysis set (FAS), the safety set (SS), the modified FAS (mFAS), and the per protocol set (PPS).
Results
348 potentially eligible subjects were enrolled. 344 subjects were included in the FAS and the SS, 340 subjects were included in the mFAS, and 328 subjects were included in the PPS. The adequate bowel preparation of OSS was equal to 3-liter PEG in the mFAS (98.22% vs. 97.66%) and the PPS (98.17% vs. 98.78%). There was no significant difference in acceptability between the two groups (94.74% vs. 94.80%, P = 0.9798). Overall adverse reactions were similar (50.88% vs. 44.51%, P = 0.2370) between the two groups.
The split-dose OSS regimen was not inferior to the split-dose 3-liter PEG regimen for the quality of bowel preparation in a Chinese adult population. The safety and acceptability of the two groups were similar.
Reference:
Peng Pan, Shengbing Zhao, Shuling Wang, Jiangbin Wang, Zhaoshen Li, Yu Bai. Comparison of the efficacy and safety of an oral sulfate solution and 3-liter polyethylene glycol on bowel preparation before colonoscopy: a phase III multicenter randomized controlled trial. Published:July 06, 2023DOI:https://doi.org/10.1016/j.gie.2023.06.070
Keywords:
Split-dose, oral sulfate, solution, regimen, effective, split-dose, 3-liter, polyethylene, glycol, regimen, preparing, bowel, colonoscopy , Colonoscopy, Bowel preparation, Oral sulfate solution, Polyethylene glycol, Gastrointestinal Endoscopy
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751