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  • Maribavir effective...

Maribavir effective against CMV infection in Hematopoietic Cell Transplant Patients

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-01-30T11:15:54+05:30  |  Updated On 30 Jan 2024 12:39 PM IST
Maribavir effective against CMV infection in Hematopoietic Cell Transplant Patients
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A recent phase 3 study found maribavir to effectively treat individuals with cytomegalovirus (CMV) infection following the hematopoietic cell transplant (HCT), with fewer treatment-limiting toxicities when compared to the commonly used valganciclovir. The findings were published in the Clinical Infectious Diseases.

This multicenter, double-blind study included patients with first asymptomatic CMV infection post-HCT and were randomized to receive either maribavir (400 mg twice daily) or valganciclovir (dose-adjusted for renal clearance) for 8 weeks, followed by an observation period of 12 weeks. The primary endpoint was to achieve confirmed CMV viremia clearance at week 8, with a noninferiority margin of 7.0%.

Maribavir did not meet the primary noninferiority endpoint (69.6% clearance compared to valganciclovir's 77.4%), but it showed comparable CMV viremia clearance during post-treatment follow-up. At week 16, the patients treated with maribavir (52.7%) and valganciclovir (48.5%) maintained CMV viremia clearance without tissue-invasive disease.

Substantial reduction in neutropenia was associated with maribavir treatment. Neutropenia occurred in only 16.1% of maribavir-treated patients when compared to 52.9% in the valganciclovir group. Also, few patients discontinued treatment due to treatment-emergent adverse events (TEAEs) with maribavir (27.8%) and valganciclovir (41.2%). Most discontinuations were linked to neutropenia, which was markedly lower in the maribavir group (4.0%) compared to valganciclovir (17.5%).

These outcomes suggest that maribavir could be a safer alternative for patients undergoing HCT who develop CMV infections. The comparable efficacy coupled with significantly fewer instances of neutropenia and discontinuations due to adverse events suggest maribavir as a promising option in the treatment of CMV post-transplantation.

Source:

Papanicolaou, G. A., Avery, R. K., Cordonnier, C., Duarte, R. F., Haider, S., Maertens, J., Peggs, K. S., Solano, C., Young, J.-A. H., Fournier, M., Murray, R. A., Wu, J., Winston, D. J., Singhal, D., Sasadeusz, J., Maertans, J., Georgala, A., Selleslag, D., Verlinden, A., … for the AURORA Trial Investigators. (2023). Treatment for first Cytomegalovirus infection post–hematopoietic cell transplant in the AURORA trial: A multicenter, double-blind, randomized, phase 3 trial comparing maribavir with valganciclovir. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. https://doi.org/10.1093/cid/ciad709

Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of Americacytomegalovirus infectionmaribavir
Source : Clinical Infectious Diseases
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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