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Statin use lowers 30-day death risk in pulmonary embolism patients: Study
![Statin use lowers 30-day death risk in pulmonary embolism patients: Study Statin use lowers 30-day death risk in pulmonary embolism patients: Study](https://medicaldialogues.in/h-upload/2020/03/14/750x450_125493-statins-2.webp)
Spain: Patients with acute pulmonary embolism (PE) using statins at baseline were found to be at significantly lower mortality risk within the first 30 days compared to non-users, says a recent study in the Journal of Thrombosis and Haemostasis. To confirm these data, randomized trials are needed.
Statins have profibrinolytic and antithrombotic properties. However, the association between the use of statins and short-term outcomes in patients with acute pulmonary embolism is not known. To fill this knowledge gap, Carmine Siniscalchi, Department of Angiology, Azienda Ospedaliera Universitaria, Parma, Italy, and colleagues aimed to compare the 30-day all-cause mortality in patients with acute PE according to the use of statins.
For this purpose, the researchers used the data from the Registro Informatizado de Pacientes con Enfermedad TromboEmbólica registry. The secondary outcome was fatal PE. Cancer-related mortality was used as a falsification endpoint.
Based on the study, the researchers reported the following findings:
- 31 169 patients with PE were recruited from January 2009 to April 2021. Of these, 5520 (18%) were using statins at baseline: low intensity: 829, moderate: 3636, high intensity: 1055.
- Statin users were older and had a higher frequency of diabetes, hypertension, or atherosclerotic disease than non-users.
- During the first 30 days, 1475 patients died (fatal PE, 255). On multivariable analysis, statin users had a lower risk of all-cause death (odds ratio [OR]: 0.65) and fatal PE (OR: 0.42) than non-users.
- The risk for death was lower in patients using either low- (OR: 0.51), moderate- (OR: 0.68), or high-intensity statins (OR: 0.68).
- Results did not change in mixed-effects logistic regression models with hospitals as a random effect.
- Statins were not associated with a significant chance in cancer mortality (falsification endpoint).
The researchers concluded, "pulmonary embolism patients using statins at baseline had a significantly lower risk of dying within the first 30 days than non-users. Randomized trials are needed to confirm these data."
Reference:
Siniscalchi C, Muriel A, Suriñach Caralt JM, Bikdeli B, Jiménez D, Lobo JL, Amado C, Gil-DÃaz A, Imbalzano E, Monreal M; and the RIETE Investigators. Statin use and 30-day mortality in patients with acute symptomatic pulmonary embolism. J Thromb Haemost. 2022 May 5. doi: 10.1111/jth.15753. Epub ahead of print. PMID: 35510755.
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751