Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Medicine
  • Medicine News
  • WHO Expands 2025...

WHO Expands 2025 Essential Medicines List, Adding Life-Saving Cancer and Diabetes Treatments

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-09-06T09:00:51+05:30  |  Updated On 6 Sept 2025 3:51 PM IST
WHO Expands 2025 Essential Medicines List, Adding Life-Saving Cancer and Diabetes Treatments
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

Switzerland: The World Health Organization (WHO) has released the executive summary report of its 25th Expert Committee meeting on the Selection and Use of Essential Medicines, held from May 5 to 9, 2025, in Geneva. These updates to the Model List of Essential Medicines (EML) and the Model List of Essential Medicines for Children (EMLc) are designed to address critical global health challenges, including the impacts of climate change, the escalating burden of chronic diseases, and cancer.

The overarching goal is to foster greater equity and access to life-saving treatments worldwide. The Model Lists serve as a crucial guide for countries and regional authorities to adapt for their national essential medicines lists, aiming to improve access, promote rational prescribing, and lower healthcare costs.

The Expert Committee's diligent review of 59 applications, including proposals for new medicines, indications, and formulations, culminated in significant revisions. Ultimately, the Committee recommended adding 20 new medicines to the EML and 15 to the EMLc, bringing the total number of medicines (including fixed-dose combinations) to 523 on the EML and 374 on the EMLc. This dynamic revision process also involved adding new indications for existing medicines, incorporating new formulations, and recommending the deletion of some medicines and formulations that were either no longer appropriate, unavailable, or posed environmental concerns.

10 Key Takeaways from the WHO Essential Medicines List Updates (2025):

1. Expanded Lists & Dynamic Revisions: The EML now totals 523 medicines (up from 502 in 2023) and the EMLc 374 (up from 361 in 2023), reflecting continuous adaptation to evolving health needs.

2. Environmental Stewardship: Halothane was removed from both lists due to its significant environmental impact as a potent greenhouse gas and ozone-depleting substance. New guidance was also issued to prioritize point-of-care cylinders for nitrous oxide to minimize waste.

3. GLP-1 Agonists for Diabetes with Comorbidities: Medicines like semaglutide, dulaglutide, liraglutide, and tirzepatide were added to the EML as add-on therapy for adults with type 2 diabetes who also have established cardiovascular disease (CVD) or chronic kidney disease (CKD) AND obesity (BMI ≥ 30kg/m2). However, they were not recommended for obesity without these specific comorbidities due to limited long-term safety and cardiovascular outcome evidence. The Committee acknowledged high costs but emphasized fostering competition through biosimilars.

4. Strategic Cancer Immunotherapy: Immune checkpoint inhibitors such as pembrolizumab, atezolizumab, and cemiplimab were included for specific metastatic cancers like non-small cell lung cancer, colorectal cancer, and cervical cancer. Strategies were outlined to improve access, including aggregating procurement of a single molecule (pembrolizumab) across multiple indications to influence price negotiations and encourage biosimilar entry.

5. Cystic Fibrosis Breakthroughs: The combination therapy elexacaftor + tezacaftor + ivacaftor and single-agent ivacaftor were added for treating cystic fibrosis in eligible patients aged 2 years and older. The Committee recognized their significant benefits but also noted high costs and the hope for generic development.

6. Enhanced Haemophilia Care: Emicizumab was added for haemophilia A, alongside recombinant coagulation factors VIII and IX. Due to its high price, the Committee suggested prioritizing emicizumab for patients with factor VIII inhibitors in resource-limited settings.

7. New Vaccines for Public Health: The lists were expanded to include vaccines for Ebola, Mpox, Hepatitis E, maternal Respiratory Syncytial Virus (RSV), and Malaria, aligning with WHO Strategic Advisory Group of Experts (SAGE) recommendations.

8. Methylphenidate for ADHD Not Recommended: The Committee did not recommend methylphenidate for Attention-Deficit Hyperactivity Disorder (ADHD) in children and adolescents, citing "limitations in the available evidence for benefits and safety of long-term use" and concerns about health system capacity in low- and middle-income settings for appropriate diagnosis and management.

9. AWaRe Antibiotic Classification Review: A comprehensive review of the AWaRe (Access, Watch, Reserve) antibiotic classification system and its definitions was requested to be considered by the 2027 Expert Committee, deferring immediate reclassification requests.

10. Triple Fixed-Dose Antihypertensives: Triple fixed-dose combination (FDC) antihypertensive formulations were added to the EML for patients with uncontrolled blood pressure on dual therapy or those at high risk (e.g., with diabetes, kidney disease, cardiovascular disease), aiming to improve adherence and simplify treatment.

These updates highlight the WHO's ongoing commitment to ensuring essential medicines meet global priority healthcare needs, balancing clinical efficacy and safety with critical considerations of affordability, access, and environmental impact.

Reference:

The selection and use of essential medicines, 2025: report of the 25th WHO Expert Committee on Selection and Use of Essential Medicines, executive summary. Geneva: World Health Organization; 2025. https://doi.org/10.2471/B09544. Licence: CC BYNC-SA 3.0 IGO.

World Health Organization (WHO)Model List of Essential Medicines (EML)Model List of Essential Medicines for Children (EMLc)cancer
Source : World Health Organization (WHO)
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

    Show Full Article
    Next Story

    Editorial

    Overcoming Antifungal Resistance: The Case for Selenium Sulfide

    Overcoming Antifungal Resistance: The Case for Selenium Sulfide

    Advancing Medical Research and Education in India: Turning Challenges into Opportunities - Prof Dr Pushpendra Nath Renjen

    Advancing Medical Research and Education in India: Turning Challenges into Opportunities - Prof Dr...

    The Prediabetes Show, Episode 4: Metformin in Prediabetes - A Vaccination Pill for Diabetes Prevention in 65 Countries

    The Prediabetes Show, Episode 4: Metformin in Prediabetes - A Vaccination Pill for Diabetes...

    Research Summit 2025: A Roadmap for Quality, Innovation and Global Recognition - Dr Soumick Ranjan Sahoo

    Research Summit 2025: A Roadmap for Quality, Innovation and Global Recognition - Dr Soumick Ranjan...

    India’s Health Horizon: From Ground Realities to Global Leadership - Dr Raghav Gupta

    India’s Health Horizon: From Ground Realities to Global Leadership - Dr Raghav Gupta

    View All

    Journal Club Today

    Meal Timing in Older Adults May Signal Health Risks: Study Finds

    Meal Timing in Older Adults May Signal Health Risks: Study Finds

    View All

    Health News Today

    Health Bulletin 06/September/2025

    Health Bulletin 06/September/2025

    View All
    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok