24-h versus PET samples: Which is better for quantification of peritoneal protein loss?

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-08T20:00:18+05:30 | Updated On 8 Sept 2022 8:00 PM IST

Portugal: Peritoneal protein loss (PPL) quantification may be expressed in accordance with a timely collection (24-h measurement or 4-h PET assessment) and as a concentration.

A recent study in the Karger journal Blood Purification has found that measurements of a 24-h sample might be closer to the clinical status and prognosis of the patient, indicating opportunities for therapy intervention. Further, the researchers found that the quantification of PET protein loss should be regarded as a marker of peritoneal membrane intrinsic permeability.

Guedes A. Malho and colleagues from Portugal aimed to compare the quantification methods of 24-h and 4-h collections. The study included 81 prevalent peritoneal dialysis patients. Registration of demographics and clinical and bioelectrical impedance features was done. Measurement of PPL (4-h PET and 24-h results) was done and peritoneal protein clearance was calculated. A linear regression model was performed.

Based on the study, the researchers found the following:

Age and continuous ambulatory peritoneal dialysis (compared to cycler) were positively associated with greater PPL on 24-h collections.
Neither cardiovascular disease, hypertension, diabetes nor the comorbidity Charlson Index was significantly associated with PPL.
There was a consistent univariable relationship with D/P creatinine, whichever sampling method was used.
Only 24-h measurements of PPL correlated with body composition variables.
In multiple linear regression analysis, D/P creatinine association with PPL stands out.
On the other hand, 24-h determinations (in grams or clearance) were associated with overhydration.
PET protein quantification was associated with peritoneal creatinine clearance.

The researchers wrote, "different methods sign different pathophysiological pathways. Quantification of PET protein loss should be regarded as a marker of peritoneal membrane intrinsic permeability."

"Measurements of a 24-h sample might be closer to patients' clinical status and prognosis, signalizing opportunities for therapy intervention," they conclude.

Reference:

The study titled, "Protein Loss in Peritoneal Effluent: Different Meaning for 24-h versus PET Samples," was published in the journal Blood Purification.

DOI: https://doi.org/10.1159/000525502

Blood Purificationperitoneal protein lossPeritoneal dialysisPET

Source : Blood Purification

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751