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  • Eculizumab Mitigates...

Eculizumab Mitigates Long-Term Kidney Damage in Pediatric Patients

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-09-22T20:00:22+05:30  |  Updated On 23 Sept 2023 4:17 PM IST
Eculizumab Mitigates Long-Term Kidney Damage in Pediatric Patients
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Shiga toxin-related hemolytic uremic syndrome (STEC-HUS), a rare and severe condition primarily affecting children, has long posed a significant medical challenge due to the lack of effective treatments. However, a recent study found eculizumab, a monoclonal antibody designed to inhibit the terminal complement complex, demonstrated promising results in reducing long-term kidney damage in pediatric patients with STEC-HUS. The findings were published in Journal of the American Society of Nephrology.

Arnaud Garnier and team initiated a Phase 3 trial involving 100 pediatric patients with STEC-HUS who were randomly assigned to receive either eculizumab or a placebo over a four-week period, with a one-year follow-up. The primary objective was to determine if eculizumab could reduce the duration of renal replacement therapy (RRT) needed within 48 hours of randomization.

The trial's results showed no significant difference in the primary endpoint between the two groups, with 48% of the placebo group and 38% of the eculizumab group requiring RRT within the specified timeframe. Moreover, there were no substantial distinctions in the course of acute renal failure or in the hematologic and extrarenal manifestations of STEC-HUS between the two groups during the acute phase of the disease.

However, the most significant finding was that the eculizumab-treated group exhibited a lower proportion of patients experiencing renal sequelae at the one-year follow-up compared to the placebo group (43.48% vs. 64.44%, respectively, p = 0.04). This suggests that while eculizumab may not improve the acute phase of STEC-HUS, it could play a role in mitigating long-term kidney damage.

One of the study's strengths was the absence of reported safety concerns associated with eculizumab treatment, indicating its potential as a safe therapeutic option for pediatric STEC-HUS patients.

The results of this Phase 3 trial are encouraging but also highlight the complexity of STEC-HUS treatment. While eculizumab did not show efficacy in reducing the need for RRT during the acute phase of the disease, it may hold promise in preventing long-term kidney sequelae.

Reference:

Garnier, A., Brochard, K., Kwon, T., Sellier-Leclerc, A.-L., Lahoche, A., Launay, E. A., Nobili, F., Harambat, J., Michel-Bourdat, G., Ulinski, T., … Brusq, C. (2023). Efficacy and Safety of Eculizumab in Pediatric Patients Affected by Shiga Toxin–Related Hemolytic and Uremic Syndrome: A Randomized, Placebo-Controlled Trial. In Journal of the American Society of Nephrology (Vol. 34, Issue 9, pp. 1561–1573). Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1681/asn.0000000000000182

Journal of the American Society of NephrologyHemolytic Uremic Syndromeeculizumab
Source : Journal of the American Society of Nephrology
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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