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Fluctuating BMI linked to poor prognosis in Chronic Kidney Disease: Study
![Fluctuating BMI linked to poor prognosis in Chronic Kidney Disease: Study Fluctuating BMI linked to poor prognosis in Chronic Kidney Disease: Study](https://medicaldialogues.in/h-upload/2021/08/23/750x450_159287-weight-and-bp.webp)
South Korean researchers found that people who had chronic kidney disease (CKD) with recent fluctuating body mass index showed higher risk of cardiovascular disease or death, without the influence of their current body mass index (BMI). They published the findings online in the Journal of American Society of Nephrology, August 2021 Issue.
In this retrospective study the authors looked into the relationship of BMI variability with risks of all-cause mortality, acute myocardial infarction, stroke, and the need for Kidney Replacement Therapy (KRT). 84,636 individuals with predialysis CKD in South Korea were included.
Variability in BMI or metabolic parameters until baseline measurement was the study exposure, which was computed as variance independent of the mean and divided into quartiles (with Q4 the highest quartile and Q1 the lowest).
o The study brought out that higher BMI variability was linked to increased risk of all-cause mortality, KRT, myocardial infarction, and stroke.
o Over the span of exposure assessment period the subgroups provided similar results regardless of the positive or negative trend in BMI.
o It was also noticed that variations in specific metabolic syndrome components such as waist circumference, fasting blood glucose, blood pressure, and lipid profile were also linked to tamper the prognosis of patients with predialysis CKD's.
o This study showed that the prognosis was worse in patients having a larger number of metabolic syndrome components with significant variability.
In conclusion, this the lead Dr. Sehoon Park pointed out that elevated variability in BMI or other metabolic parameters was associated with higher risks of adverse outcomes, regardless of the baseline metabolic status. Since these findings interact with potential prognostic significance it can greatly help clinicians to carefully assess baseline BMI, the metabolic status in patients with CKD and also the fluctuating status of metabolic parameters in such patients.
Reference
Park, S., Cho, S., Lee, S., Kim, Y., Park, S., Kim, Y. C., Han, S. S., Lee, H., Lee, J. P., Joo, K. W., Lim, C. S., Kim, Y. S., Han, K., & Kim, D. K. (2021). The Prognostic Significance of Body Mass Index and Metabolic Parameter Variabilities in Predialysis CKD: A Nationwide Observational Cohort Study. Journal of the American Society of Nephrology, ASN.2020121694. https://doi.org/10.1681/asn.2020121694
Dr Kartikeya Kohli is an Internal Medicine Consultant at Sitaram Bhartia Hospital in Delhi with super speciality training in Nephrology. He has worked with various eminent hospitals like Indraprastha Apollo Hospital, Sir Gangaram Hospital. He holds an MBBS from Kasturba Medical College Manipal, DNB Internal Medicine, Post Graduate Diploma in Clinical Research and Business Development, Fellow DNB Nephrology, MRCP and ECFMG Certification. He has been closely associated with India Medical Association South Delhi Branch and Delhi Medical Association and has been organising continuing medical education programs on their behalf from time to time. Further he has been contributing medical articles for their newsletters as well. He is also associated with electronic media and TV for conduction and presentation of health programs. He has been associated with Medical Dialogues for last 3 years and contributing articles on regular basis.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751