Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Webinars
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Neurology and Neurosurgery
  • Neurology & Neurosurgery News
  • Study finds early...

Study finds early menopause is associated with increased risk of dementia

Written By : Dr. Kamal Kant Kohli Published On 2025-10-21T21:00:38+05:30  |  Updated On 21 Oct 2025 9:01 PM IST
Study finds early menopause is associated with increased risk of dementia
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

A new international study led by University of Galway has found that entering menopause at an earlier age is associated with an increased risk of dementia.

The research also showed that hormone replacement therapy (HRT) after menopause appears to be associated with a reduced risk of dementia.

The findings have been published today in the Journal for Alzheimer’s Disease.

The research team from University of Galway and Boston University carried out the study with 1,329 cognitively healthy women from The Framingham Heart Study - the world’s longest running longitudinal cohort study - to analyse the association between reproductive factors and markers of brain aging.

It found:

• Entering menopause at an earlier age is associated with an increased risk of dementia.

• HRT after menopause appears to be associated with a reduced risk of dementia.

• Greater exposure to estrogen over the reproductive lifespan was associated with enhanced cognitive performance and larger brain volumes.

• Having more children, higher blood oestrogen levels and being older at the time of menopause were also associated with better cognitive test performance, specifically better visuospatial skills - the ability to perceive, analyse and mentally manipulate visual and spatial information.

Professor Emer McGrath, lead author and Associate Professor in Medicine, College of Medicine, Nursing & Health Sciences, University of Galway, and Consultant Neurologist, Galway University Hospital, said: “Our study explored the association between reproductive and hormonal factors across a woman’s lifespan and risk of brain aging. We looked at neurocognitive and neuroimaging markers from MRI brain scans, as well as cognitive test performance, including tests of memory, reasoning skills and visuospatial skills. We also looked at the future risk of dementia in relation to these reproductive factors.

“We found that entering menopause at an earlier age appears to be associated with an increased risk of dementia, while post-menopause hormone replacement therapy appears to be associated with a lower risk of dementia. Although our results suggest positive cognitive benefits of greater lifetime estrogen exposure, they do require further validation.”

Women have a higher risk of dementia compared to men, with women accounting for almost two thirds of those living with Alzheimer’s disease.

The research involved women from the Framingham Heart Study and investigated the age at the time of a woman’s first period; the age at onset of menopause; the duration of a woman’s reproductive lifespan; levels of oestrogen in the blood; and whether a woman used post-menopausal hormone replacement therapy or not. These factors were then related to performance on neurocognitive testing, signs of brain shrinkage on MRI scans and a woman’s future risk of developing dementia.

Professor Emer McGrath said: “When we explored signs of brain ageing on MRI brain scans, we also found that having more children was associated with larger brain volumes, including in the areas we tend to see shrinkage in Alzheimer’s disease.”

Despite its public health importance, our understanding of an association with sex related differences in Alzheimer’s disease and related dementias significantly lags behind that in the cardiovascular field. While longer life expectancy in women may explain some of the higher risk in women, factors including reproductive health and hormonal levels in women may play an important role.

Reference:

Emer R McGrath , Matthew R Scott, The association between reproductive factors and neurocognitive and neuroimaging markers of brain aging, Journal for Alzheimer’s Disease, https://doi.org/10.1177/13872877251372430

Journal for Alzheimer’s Diseasemenopausedementiahormone replacement therapybrain aging
Source : Journal for Alzheimer’s Disease
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

Show Full Article
Next Story

Editorial

EASD 2025: First-Ever Guidelines Released to Address Diabetes Distress

EASD 2025: First-Ever Guidelines Released to Address Diabetes Distress

PRO-ACT Study Compares Topical Minoxidil 5% with PRCT vs Plain Minoxidil 5% in Androgenetic Alopecia-Combination Shows Superior Efficacy

PRO-ACT Study Compares Topical Minoxidil 5% with PRCT vs Plain Minoxidil 5% in Androgenetic...

DAa-ViNCI Study: Real-World Data shows Efficacy of Vildagliptin-  Dapagliflozin FDC among High-CV Risk T2D in Indian Cardiology  Settings

DAa-ViNCI Study: Real-World Data shows Efficacy of Vildagliptin- Dapagliflozin FDC among High-CV...

Indias Unique CV Risk Profile: How to Decode the Role of Aspirin?

India's Unique CV Risk Profile: How to Decode the Role of Aspirin?

Vildagliptin-Dapagliflozin FDC Effective in High CV Risk Indian T2DM Patients: Findings from Latest DAa-ViNCI Study

Vildagliptin-Dapagliflozin FDC Effective in High CV Risk Indian T2DM Patients: Findings from Latest...

View All

Journal Club Today

Long-term Exercise Keeps Immune System Younger and Sharper: Study Finds

Long-term Exercise Keeps Immune System Younger and Sharper: Study Finds

View All

Health News Today

Health Bulletin 18/October/2025

Health Bulletin 18/October/2025

View All
© 2022 All Rights Reserved.
Powered By: Hocalwire
X
We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok