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COVID vaccine shows better immune response with two-dose regime: Oxford
London: Oxford's Covid-19 vaccine candidate has a better immune response when a two full-dose regime is used rather than a full-dose followed by a half-dose booster, the university said on Thursday.
The vaccine candidate, which has been licensed to AstraZeneca, has published interim late stage trial results showing higher efficacy when a half dose is followed by a full dose, compared to a two full-dose regime, though more work needs to be done to affirm the result.
The details from the Phase I/II clinical trials released on Thursday made no reference to the half-dose/full-dose regime, which Oxford has said had been "unplanned" but approved by regulators.
The university said it had explored two dosing regimes in early stage trials, a full-dose/full-dose regime and a full-dose/half-dose regime, investigated as a possible "dose sparing" strategy.
"The booster doses of the vaccine are both shown to induce stronger antibody responses than a single dose, the standard dose/standard dose inducing the best response," the university said in a statement.
The vaccine "stimulates broad antibody and T cell functions," it said after publishing further data from the Phase I/II clinical trials.
Read also: AstraZeneca gets EU nod for Trixeo Aerosphere to treat COPD
Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751
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