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Wockhardt Zaynich successfully treats paediatric cancer patient with recalcitrant blood, liver infection

The patient was treated with Zaynich for 41 days, resulting in the successful resolution of the infection.
Mumbai: Wockhardt has announced that a 15-year-old US patient with Acute Myeloid Leukemia (AML), a type of blood and bone marrowcancer, has been successfully cured of a severe, drug-resistant infection following treatment with Zaynich (Zidebactam/Cefepime, WCK 5222) under compassionate use.
The patient, who had not responded to nine antibiotics across five different classes over a span of 45 days, was left with few treatment options before Zaynich was administered.
This case, treated at St. Jude's Hospital in Memphis, USA, involved a severely immunocompromised patient due to chemotherapy. The infection was traced to abscesses in the liver, which led to recurrent bloodstream infections caused by E. coli producing NDM, a highly resistant variant of metallo-β-lactamase (MBL). Despite the use of multiple antibiotics, including Tigecycline, Plazomicin, Levofloxacin, Cefepime, Gentamicin, Eravacycline, Polymyxin B, and Ceftazidime/avibactam + Aztreonam, the infection persisted.
Given the patient’s critical condition, the medical team sought approval from the US FDA for the compassionate use of Zaynich. Following the approval, the patient was treated with Zaynich for 41 days, resulting in the successful resolution of the infection and a stabilization of the patient's clinical condition. This marks the third US patient to benefit from Zaynich which is attributable to its unique β-lactam enhancer mechanism.
To date, 51 patients with life-threatening Gram-negative infections have been treated successfully under the compassionate use of Zidebactam/Cefepime, demonstrating its potential in combating drug-resistant infections.
Zaynich is a novel, proprietary antibiotic developed by Wockhardt, combining Zidebactam and Cefepime, designed to target multi-drug resistant Gram-negative infections. The drug has recently completed a global, pivotal Phase III study, which is set to support its marketing authorization worldwide. Prior to this, several Phase I clinical pharmacology studies involving Zidebactam/Cefepime were successfully conducted in the United States. Additionally, Zaynich has completed a multi-indication clinical study in India, focusing on the treatment of carbapenemresistant infections.
Ruchika Sharma joined Medical Dialogue as an Correspondent for the Business Section in 2019. She covers all the updates in the Pharmaceutical field, Policy, Insurance, Business Healthcare, Medical News, Health News, Pharma News, Healthcare and Investment. She has completed her B.Com from Delhi University and then pursued postgraduation in M.Com. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751