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  • Exposure to marijuana...

Exposure to marijuana in pregnancy tied with adverse neonatal outcomes: JAMA

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-02-22T09:00:13+05:30  |  Updated On 22 Feb 2022 9:00 AM IST
Exposure to marijuana in pregnancy tied with adverse neonatal outcomes: JAMA
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Exposure to marijuana in pregnancy is tied with adverse neonatal outcomes, according to a recent study published in the JAMA Network Open.

While some studies have found an association between marijuana use and adverse neonatal outcomes, results have not been consistent across all trials.

A study was conducted to assess available data on neonatal outcomes in marijuana-exposed pregnancies.

PubMed, Medline, ClinicalTrials.gov, Cochrane, Scopus, and Web of Science were searched from each database's inception until August 16, 2021. All interventional and observational studies that included pregnant women who were exposed to marijuana compared with pregnant women who were not exposed to marijuana and that reported neonatal outcomes were included.

Reporting followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guideline. Data were extracted by 2 authors for all outcomes, which were pooled using a random-effects model as mean difference or risk ratio (RR) and 95% CI. Data were analyzed from August through September 2021.

All outcomes were formulated prior to data collection. Outcomes included incidence of birth weight less than 2500 g, small for gestational age (defined as less than the fifth percentile fetal weight for gestational age), rate of preterm delivery (defined as before 37 weeks gestation), gestational age at the time of delivery, birth weight, the incidence of neonatal intensive care unit (NICU) admission, Apgar score at 1 minute, Apgar score at 5 minutes, the incidence of an Apgar score less than 7 at 5 minutes, fetal head circumference, and fetal length.

Results:

Among 16 studies including 59 138 patients, there were significant increases in 7 adverse neonatal outcomes among women who were exposed to marijuana during pregnancy vs those who were not exposed during pregnancy. These included increased risk of birth weight less than 2500 g small for gestational age, preterm delivery, and NICU admission, along with decreased mean birth weight, Apgar score at 1 minute, and infant head circumference.

Thus, this study found that women exposed to marijuana in pregnancy were at a significantly increased risk of some adverse neonatal outcomes. These findings suggest that increasing awareness about these risks may be associated with improved outcomes.

Reference:

Birth Outcomes of Neonates Exposed to Marijuana in Utero: A Systematic Review and Meta-analysis by Greg Marchand, et al. published in the JAMA network open.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788451


JAMA Network openBirth OutcomesNeonatesMarijuanain Uteroexposurepregnancy
Source : JAMA Network open
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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