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  • Severe glaucoma and...

Severe glaucoma and younger age associated with microcystic macular edema: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-04-26T12:30:21+05:30  |  Updated On 27 April 2022 9:52 AM IST
Severe glaucoma and younger age associated with microcystic macular edema: Study
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More severe glaucoma and younger age is associated with microcystic macular edema (MME) according to a recent study published in the British Journal of Opthalmology.

A study was conducted to identify clinical characteristics and factors associated with microcystic macular edema (MME) in patients with primary open-angle glaucoma (POAG).

They included 315 primary open-angle glaucomas (POAG) eyes between 2010 and 2019 with good-quality macular volume scans that had reliable visual fields (VF) available within 6 months in this observational retrospective cohort study. Eyes with retinal pathologies except for epiretinal membrane (ERM) were excluded. The inner nuclear layer was qualitatively assessed for the presence of microcystic macular edema (MME). Global mean deviation (MD) and Visual Field Index (VFI) decay rates, superior and inferior MD rates and pointwise total deviation rates of change were estimated with linear regression. Logistic regression was performed to identify baseline factors associated with the presence of MME and to determine whether microcystic macular edema (MME) is associated with progressive VF loss.

Results of the study are:

  • 25 out of 315 eyes (7.9%) demonstrated microcystic macular edema (MME).
  • The average (±SD) age and mean deviation (MD) in eyes with and without MME was 57.2 (±8.7) versus 62.0 (±9.9) years (p=0.02) and −9.8 (±5.7) versus −4.9 (±5.3) dB (p<0.001), respectively.
  • Worse global MD at baseline (p=0.001) and younger age (p=0.02) were associated with the presence of microcystic macular edema (MME).
  • ERM was not associated with the presence of MME (p=0.84) in this cohort.
  • Microcystic macular edema (MME) was not associated with mean deviation (MD) and Visual Field Index (VFI) decay rates (p>0.49).

Thus, more severe glaucoma and younger age were associated with microcystic macular edema (MME). Microcystic macular edema (MME) was not associated with faster global Visual Field VF decay in this cohort. Microcystic macular edema (MME) may confound monitoring of glaucoma with full macular thickness.

Reference:

Risk factors for microcystic macular oedema in glaucoma by Golnoush Mahmoudinezhad et al. published in the British Journal of Ophthalmology.

doi: 10.1136/bjophthalmol-2021-320137

Keywords:

Golnoush Mahmoudinezha, Diana Salazar, Esteban Morales, Peter Tran, Janet Lee, Jean-Pierre primary open-angle glaucoma (POAG), Microcystic macular edema, MME, retinal pathologies, Visual Field, Visual Field index, decay rates, Hubschman, Kouros Nouri-Mahdavi, Joseph Caprioli, glaucoma, edema, Risk factors, macular, microcystic, British Journal of Ophthalmology


British Journal of OphthalmologyglaucomaedemaRisk factorsmicrocystic
Source : British Journal of Ophthalmology
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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