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  • Probiotic treatment...

Probiotic treatment alone fails to decrease risk of severe acute gastroenteritis: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-11-09T09:00:17+05:30  |  Updated On 23 March 2022 5:06 PM IST
Probiotic treatment alone fails to decrease risk of severe acute gastroenteritis: Study
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Among children with acute gastroenteritis, probiotic treatment with either combination Lactobacillus rhamnosus and L helveticus or L rhamnosus GG alone did not result in a decreased risk for severe disease compared with placebo, according to results of a study published in Clinical Infectious Diseases.

It is unknown if probiotics exert pathogen-specific effects in children with diarrhea secondary to acute gastroenteritis.

Analysis of patient-level data from two multi-center randomized, placebo controlled, trials conducted in pediatric emergency departments in Canada and the U.S.. Participants were 3-48 months with >3 diarrheal episodes in the preceding 24 hours, and were symptomatic for <72 hours and <7 days in the Canadian and U.S. studies, respectively. Participants received either placebo or probiotic preparation (Canada-Lactobacillus rhamnosus R0011/L. helveticus R0052; U.S.-L. rhamnosus GG). The primary outcome was post-intervention moderate-to-severe disease.

The Results of the study are as follows:

  • Pathogens were identified in specimens from 59.3% (928/1565) children.
  • No pathogen groups were less likely to experience an MVS ≥9 based on treatment allocation.
  • No differences between groups were identified for adenovirus, norovirus, rotavirus, or bacteria.
  • At pathogen-group and among individual pathogens there were no differences in diarrhea duration or the total number of diarrheal stools between treatment groups, regardless of intervention allocation or among probiotic sub-groups. Among adenovirus-infected children, those administered the Lactobacillus rhamnosus R0011/L. helveticus R0052 product experienced fewer diarrheal episodes.

Thus, the researchers concluded that neither probiotic product resulted in less severe disease compared to placebo across a range of the most common etiologic pathogens. Clarifying the etiology of diarrhea among those without pathogens identified is warranted. According to the researchers, "the preponderance of the evidence does not support the notion that there are pathogen-specific benefits associated with probiotic use in children with [acute gastroenteritis]."

Reference:

Pathogen-Specific Effects of Probiotics in Children with Acute Gastroenteritis Seeking Emergency Care: A Randomized Trial by Stephen B Freedman et al. published in the Clinical Infectious Diseases

https://doi.org/10.1093/cid/ciab876


probiotic treatmentdecreased risksevere diseaseacute gastroenteritisjournal of Clinical Infectious Diseasesgastroenteritisacuteadeno virusesdiarrheaCanadachildemergencytreatmentnorovirusrotaviruspathogenicorganismaldosterone-reninratioabsolute riskreductionlactobacillus rhamnosus
Source : Clinical Infectious Diseases
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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