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  • Fluoxetine effective...

Fluoxetine effective and safe in children with refractory Nocturnal Enuresis, Recommends study

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-11-05T12:15:05+05:30  |  Updated On 5 Nov 2022 12:04 PM IST
Fluoxetine effective and safe in children with refractory Nocturnal Enuresis, Recommends study
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Egypt: A study published in the Journal of Urology has concluded the safety of Fluoxetine, which is a selective serotonin reuptake inhibitor, SSRI in children for the management of refractory primary monosymptomatic nocturnal enuresis (PMNE).

Nocturnal enuresis (NE) affects 15% of children. The condition has negative psychological, emotional, and social impacts. The treatment improves a child's self-esteem and mental health.

Alarm therapy, desmopressin, anticholinergics, and tricyclic antidepressants are the standard treatment options available. But the treatment efficacy remains limited, and nearly 50% of children are refractory to treatment, while treatment discontinuation leads to higher relapse rates.

The anti-enuretic effect of Fluoxetine was first reported by Mesaros.The literature mentions conflicting results with SSRIs like sertraline, fluvoxamine, and paroxetine to treat NE.

Based on the above background, a study was conducted by researchers. It was led by Dr. Mohamed Hussiny and Dr. Abdelwahab Hashem from the Department of Urology at Mansoura University to evaluate the fluoxetine efficacy and safety in children for treating PMNE.

The main points of research are:

• Children aged 8-18 years with severe PMNE history of being unresponsive to alarm therapy, desmopressin, and anticholinergics were screened for the study.

• A total of 150 children were enrolled. There were two groups: the Fluoxetine group (56 children) and the Placebo group (54 children).

• Patients were given 10 mg of fluoxetine once daily for 12 weeks.

• The primary outcome was treatment response (International Children's Continence Society terminology).

• The secondary outcomes measured were adverse effects and nighttime arousal.

• The complete and partial responses achieved in the fluoxetine group and placebo group after four weeks was 7.1% and 66.1 versus 0% and 16.7%, respectively. The P value was <0 .001.

• At 12 weeks, complete and partial responses in the fluoxetine and placebo group were 10.7% and 21.4% vs. 0% and 14.8%, respectively. The P value was 0.023. This significantly indicated declined response rate.

• Patients in the fluoxetine group had a lower number of wet nights at 4, 8, and 12 weeks of treatment than placebo, with p values <0.001, <0.001, and 0.003, respectively.

• The mean number of wet nights in Fluoxetine-treated patients was worse at 12 weeks compared to 4 weeks of treatment.

• In the fluoxetine group, after 4 and 8 weeks, improved arousal was 10.7%.

• After 12 weeks, improved arousal was 14.3% in the fluoxetine group compared to 1.9% in the placebo (P = .017).

They wrote, "The number of wet nights was significantly reduced in the fluoxetine group than placebo."

The researchers explained that Fluoxetine is a safe treatment modality for refractory PMNE children and is associated with the good initial response. The response declines at 12 weeks. The response to fluoxetine therapy is not significantly associated with the age, gender, BMI, family history, etc., they mentioned.

Further reading:

The Safety and Efficacy of Fluoxetine for the Treatment of Refractory Primary Monosymptomatic Nocturnal Enuresis in Children. Mohamed Hussiny et al.

FluoxetineJournal of UrologyPMNErefractory primary monotherapy nocturnal enuresis
Source : Journal of Urology
Aditi
Aditi

    BDS, MDS in Periodontics and Implantology

    Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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