H. pylori stool antigen and fecal immunochemical tests combo fails to lower gastric cancer mortality: JAMA
A new study published in the Journal of American Medical Association showed that the combination of testing for H pylori stool antigen (HPSA) and fecal immunochemical tests (FIT) did not lower the incidence of stomach cancer or gastric cancer death when compared to a FIT invitation alone.
It is uncertain how Helicobacter pylori screening affects the incidence and death of stomach cancer. This study was carried out to determine if, among the individuals invited for fecal immunochemical testing-based colon cancer screening, the rates of gastric cancer incidence and death are lower when FIT is combined with a stool antigen test for Helicobacter pylori.
This practical randomized clinical study included the inhabitants of Taiwan between the ages of 50 and 69 who are qualified for biannual fecal immunochemical testing (FIT) for the detection of colon cancer. FIT evaluation alone or an invitation for H. pylori stool antigen (HPSA)+FIT examination was given to participants at random. Between January 1, 2014, and September 27, 2018, this study was carried out. The last follow-up took place on December 31, 2020. Invitation for testing for H. pylori stool antigen was the major intervention technique. The incidence and mortality of stomach cancer were the main results. Every invited person was examined in accordance with the groups to which they were randomly assigned.
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