Study Finds Estrogen Blockers Do Not Elevate Coronary Heart Disease Risk in Breast Cancer Cases
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New evidence shows that extended estrogen suppression treatment using aromatase inhibitors for hormone receptor-positive postmenopausal breast cancer is safe; it does not increase the risk of coronary artery calcification, a sign of active coronary atherosclerosis, as some prior studies had indicated.
An article in the Canadian Journal of Cardiology, details the findings from a retrospective, cross-sectional observational study that investigated the association between the duration of aromatase inhibitor treatment and the severity of coronary artery calcification in postoperative breast cancer patients.
Lead investigator Yu Hiasa, MD, Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine, Toon, Japan, explains, “Although there is an ongoing discussion on the optimal duration of aromatase inhibitor therapy (5 years or 10 years), our data suggest that longer aromatase inhibitor use (as often used to prevent or suppress late recurrences or spread of breast cancer) is safe, at least in regard to coronary artery calcification.”
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