Antioxidants Help Prevent High-Fat Diet-Induced Reproductive Issues, Study reveals
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In a systematic review published in the journal Frontiers in Nutrition, researchers conducted a comprehensive assessment of the role of antioxidants in mitigating female reproductive complications induced by high-fat diets.
These diets, abundant in saturated and trans fats, are known to generate reactive oxygen species (ROS) that induce oxidative stress. This oxidative stress disrupts the female reproductive system by causing irregular ovulation, premature ovarian failure, impairing blood flow to reproductive organs, and disrupting the hypothalamic-pituitary-ovarian axis. Consequently, hormonal imbalances, insulin resistance, and inflammation can affect oocyte quality and compromise pregnancy maintenance.
Biological matrices containing antioxidants such as carbocyclic sugars, phytonutrients, organosulfur compounds, hormones, neuropeptides, organic acids, and vitamins have been identified as potential countermeasures against ROS-induced damage.
The systematic review involved an analysis of data from 121 studies to evaluate the effectiveness of these biological matrices in preventing ovarian complications resulting from high-fat diet-induced oxidative stress.
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