Ticagrelor treatment decreases osteoarthritis risk, finds new study
USA: A five-year-long study found ticagrelor treatment to be associated with a 29% lower risk of developing osteoarthritis (OA) compared to clopidogrel. The study is published in the journal Arthritis & Rheumatology. The researchers hypothesized that OA reduction in patients who received ticagrelor could be partly due to increased extracellular adenosine.
Osteoarthritis, a degenerative joint disease, is a common cause of disability and joint pain. Despite this, effective treatments for the condition are lacking. Extracellular adenosine has anti‐inflammatory effects and can treat and prevent OA in animal models. Clopidogrel and ticagrelor are used for the treatment of coronary artery disease but only ticagrelor increases extracellular adenosine.
Matthew C. Baker, Stanford University, Stanford, California, United States, and colleagues determined whether treatment with ticagrelor was associated with a lower risk of OA.
The researchers conducted a 1:2 propensity score matching analysis using the Optum Clinformatics Data Mart from 2011 to 2017. Patients who received either ticagrelor or clopidogrel for at least 90 days were included. Those having a prior diagnosis of OA or inflammatory arthritis were excluded. OA was identified using the International Classification of Diseases codes.
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