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  • Concurrent ICDs...

Concurrent ICDs placement renders primary prevention among HF patients, reveals research

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-07-09T09:30:25+05:30  |  Updated On 9 July 2024 12:25 PM IST
Concurrent ICDs placement renders primary prevention among HF patients, reveals research
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Researchers in a recent study have found that implantable cardioverter-defibrillators (ICDs) continue to offer a significant mortality benefit for patients with a primary prevention (PP) indication in heart failure management. The study was published in the journal JACC: Clinical Electrophysiology conducted by Aamir Ahmed and colleagues. This study reaffirms the life-saving potential of ICDs, consistent with earlier clinical trials.

Previous clinical trials established the efficacy of ICDs in reducing sudden cardiac death among high-risk patients. However, since those studies, there have been notable advancements in heart failure (HF) treatment and ICD technology, necessitating an updated evaluation of ICD benefits.

The primary aim of this study was to compare mortality rates between patients with a primary prevention indication for an ICD who received the device and those who did not, using contemporary real-world data. The study analyzed data from a large electronic health record database of U.S. patients between 2012 and 2020. Included patients had a PP indication for ICD and survived at least one year post-indication.

The study findings were as follows:

• A total of 25,296 patients met the inclusion criteria. Among them, 2,118 (8.4%) received an ICD within a year of indication.

• The treated group was younger (average age 63.4 years) compared to the non-treated group (average age 66.1 years) and had a smaller proportion of women (25.0% vs 36.7%).

• After adjusting for clinical characteristics through 4-to-1 propensity matching, the study employed a Cox proportional hazard model to estimate the impact of ICD treatment on mortality.

• Patients treated with an ICD had a 24.3% lower risk of all-cause mortality compared to those who did not receive the device (HR: 0.757; 95% CI: 0.678-0.835; P < 0.001).

• There was no significant difference in ICD benefit between patients with ischemic and nonischemic heart disease (P = 0.50).

The absence of differential benefit between ischemic and nonischemic heart disease patients suggests a broad applicability of ICDs across different heart failure etiologies. ICD therapy for patients with a primary prevention indication is associated with a significant reduction in all-cause mortality.

Reference:

Ahmed, A., Auricchio, A., Mittal, S., Pickett, R. A., Wilkoff, B. L., Jacobsen, L. D., Marti, A. K., Holbrook, R. W., Soderlund, D. M., & Curtis, A. B. (2024). Mortality benefit among primary prevention implantable cardioverter-defibrillator recipients on contemporary heart failure treatment. JACC. Clinical Electrophysiology, 10(5), 916–926. https://doi.org/10.1016/j.jacep.2024.102334


JACC: Clinical ElectrophysiologyImplantable cardioverter-defibrillatorICDheart failuremortalityprimary preventionreal-world datapropensity matchingischemic heart diseasenonischemic heart disease
Source : JACC: Clinical Electrophysiology
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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