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  • Neonatal BCG vaccine...

Neonatal BCG vaccine protects against early-life eczema, study says

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-10-14T03:00:52+05:30  |  Updated On 15 Feb 2024 8:54 AM IST
Neonatal BCG vaccine protects against early-life eczema, study says
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Australia: Neonatal bacillus Calmette-Guérin (BCG) vaccination may reduce the incidence of atopic dermatitis and should be considered for children of atopic parents, a recent study in the Dermatitis journal has suggested.

Neonatal BCG vaccination, one of the most widely used vaccines globally, has been reported to have beneficial effects beyond preventing infantile tuberculous meningitis and miliary disease. Atopic dermatitis, also known as eczema, is a skin condition that causes itchy, dry, and inflamed skin. It commonly occurs in young children but can occur at any age. The state is chronic (long-lasting) and sometimes tends to flare. It can be irritating but not contagious.

Accumulated evidence has suggested that early life BCG vaccine could prevent atopic eczema via its beneficial off-target effects. The meta-analysis by Laure F Pittet, Department of Paediatrics, The University of Melbourne, Australia, and colleagues, included three randomized control trials with similar methods and enabled robust estimations with low heterogeneity. It included a total of 5655 children randomized to early-life BCG Denmark (n = 2832) or no BCG (n = 2823).

The findings indicate a beneficial effect of BCG for eczema prevention (risk ratio [RR], 0.89). In subgroup analyses, BCG was more useful in boys (RR, 0.84) and children born to atopic parents (RR, 0.81). The number needed to treat (NNT) to prevent one eczema case among children of 1 or 2 atopic parents was 20. Bacillus Calmette-Guérin Denmark resulted in an 11% reduction in eczema risk in early life. A more significant effect was seen with an increased predisposition.

The researchers conclude, "given its well-established safety profile, neonatal BCG vaccination should be considered for children of atopic parents."

Reference:

Pittet, Laure F. MD, PhD∗,†,‡,§; Thøstesen, Lisbeth M. MD, PhD∥; Aaby, Peter DMSc; Kofoed, Poul-Erik MD, DMSc#; Curtis, Nigel FRCPCH, PhD∗,†,‡; Benn, Christine S. MD, DMSc∗∗,††. Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis. Dermatitis: September 22, 2022 - Volume - Issue - 10.1097/DER.0000000000000945 doi: 10.1097/DER.0000000000000945

Dermatitis journalBCG vaccinationatopic dermatitis
Source : Dermatitis journal
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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