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  • High-dose SGLT2...

High-dose SGLT2 inhibitors tied to superior blood sugar control in type 2 diabetes: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-06-21T11:44:40+05:30  |  Updated On 21 Jun 2021 11:44 AM IST
High-dose SGLT2 inhibitors tied to  superior blood sugar control in type 2 diabetes: Study
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China: The use of clinically approved high-dose SGLT2 inhibitors may help in improving blood sugar levels, body weight and blood pressure in patients with poorly controlled diabetes, suggests a recent study.

The study, published in the journal Diabetes, Obesity & Metabolism, found that the overall efficacy of SGLT2 inhibitors mainly empagliflozin, dapagliflozin, and canagliflozin is dose-dependent.

Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a new class of oral hypoglycaemic drugs. It is initially recommended to diabetes patients with cardiovascular disease or to those previously subjected to metformin-based treatment. SGLT2 inhibitors exert beneficial effects on the regulation of blood pressure, body weight, and blood sugar. However, it is not certain whether the effects are dose-dependent.

To fill this knowledge gap, Zhi-Chun Gu, Shanghai Jiaotong University, Shanghai, China, and colleagues aimed to determine the overall efficacy of high-dose versus low-dose SGLT2 inhibitors in patients with type 2 diabetes mellitus (T2DM).

For this purpose, the researchers searched the online databases between 1 January 2006 and 23 September 2020. Prespecified subgroup analyses for each SGLT2 inhibitor, follow-up, and controls were performed. Leave-one-out sensitivity and meta-regression analyses were conducted. The meta-analysis included a total of 51 randomized controlled trials involving 23989 participants.

Key findings of the study include:

  • For glycaemic regulation ability, a significant reduction in glycosylated haemoglobin (MD –0.080%), fasting plasma glucose (MD –0.227 mmol/L), and postprandial plasma glucose (MD –0.834 mmol/L) levels was observed in the high-dose SGLT2 inhibitor group.
  • Treatment with high-dose SGLT2 inhibitors enabled easier achievement of the target (HbA1c% < 7) than low-dose SGLT2 inhibitors (RR 1.148).
  • High-dose SGLT2 inhibitor-based treatment resulted in more efficient regulation of body weight and blood pressure (body weight: MD –0.346 kg; SBP: MD –0.583 mmHg; DBP: MD –0.352 mmHg).
  • The results were similar in sensitivity analyses.

"Our findings showed that the overall efficacy of SGLT2 inhibitors, mainly canagliflozin, dapagliflozin, and empagliflozin are dose-dependent," concluded the authors.

Reference:

The study titled, "High-Dose Sodium-Glucose Co-transporter 2 Inhibitors are Superior in Type 2 Diabetes: A Meta-analysis of Randomised Clinical Trials," is published in the journal Diabetes, Obesity & Metabolism.

DOI: https://dom-pubs.onlinelibrary.wiley.com/doi/pdf/10.1111/dom.14452


Diabetes Obesity & MetabolismSGLT2 inhibitorstype 2 diabetesblood sugarsodium-glucose transporter 2 inhibitorsHigh dose SGLT2 inhibitors
Source : Diabetes, Obesity & Metabolism
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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