Women with high BP during pregnancy may develop diabetes later on: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-02-24T11:45:39+05:30 | Updated On 24 Feb 2021 2:03 PM IST

Canada: Women with prior hypertensive disorders of pregnancy (HDP) are at higher risk of developing type 2 diabetes, finds a recent study in the journal Diabetologia. The study results indicate that postpartum diabetes prevention and screening counseling may be warranted in women with a history of hypertensive disorders of pregnancy (HDP).

The association between a history of HDP and subsequent type 2 diabetes remains inconclusive. Grace Zhao, University of Toronto, Toronto, ON, Canada, and colleagues reviewed the most recent evidence to quantify the association of previous HDP with incident diabetes.

For the purpose, the researchers performed a systematic search of online databases up to 17 February 2020 and identified observational studies of the association between HDP (pre-eclampsia or gestational hypertension) and incident diabetes. It excluded studies of women with pre-pregnancy diabetes.

Two independent reviewers screened citations and abstracted results. Study quality was assessed in duplicate using the Newcastle–Ottawa Scale. Random-effects models were used to pool effect estimates. Heterogeneity was assessed using the I2 statistic.

The researchers included 16 cohort studies with a total of 3,095,457 participants (unspecified HDP n = 5, pre-eclampsia only n = 4, gestational hypertension and pre-eclampsia n = 7) after screening 4617 citations.

Key findings of the study include:

Risks of subsequent diabetes were significantly higher in women with a history of any HDP (HDP: adjusted hazard ratio [aHR] 2.24; gestational hypertension: aHR 2.19; pre-eclampsia: aHR 2.56; preterm pre-eclampsia: aHR 3.05).
The association between HDP and diabetes persisted in studies that adjusted for gestational diabetes mellitus (aHR 2.01).

"HDP are independently associated with a higher risk of diabetes. Further study is needed to determine how HDP contribute to diabetes risk prediction to develop evidence-based screening and prevention strategies," concluded the authors.

The study titled, "Risk of type 2 diabetes mellitus in women with prior hypertensive disorders of pregnancy: a systematic review and meta-analysis," is published in the journal Diabetologia.

DOI: https://link.springer.com/article/10.1007/s00125-020-05343-w

Diabetologiahypertensionpregnancytype 2 diabetesHypertensive disorder of pregnancy

Source : Diabetologia

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751