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Coffee and chemical in fast foods tied with breast cancer risk
Chemical in fast foods and coffee are tied with breast cancer risk according to a recent study published in the American Journal of Clinical Nutrition
Acrylamide is classified as a probable human carcinogen by the International Agency for Research on Cancer but epidemiologic evidence on the carcinogenicity of acrylamide from dietary sources is limited.
This study aimed to investigate the associations between dietary acrylamide and breast cancer risk in the NutriNet-Santé cohort, accounting for menopausal and hormone receptor status.
This prospective cohort study included 80,597 French females (mean ± SD age at baseline: 40.8 ± 14 y) during a mean ± SD follow-up of 8.8 ± 2.3 y. Acrylamide intake was evaluated using repeated 24-h dietary records (n ± SD = 5.5 ± 3.0), linked to a comprehensive food composition database. Associations between acrylamide intake and breast cancer risk (overall, premenopausal, and postmenopausal) were assessed by Cox hazard models adjusted for known risk factors (sociodemographic, anthropometric, lifestyle, medical history, and nutritional factors).
Results:
- The mean ± SD dietary acrylamide intake was 30.1 ± 21.9 µg/d
- During follow-up, 1016 first incident breast cancer cases were diagnosed
- A borderline significant positive association was observed between dietary acrylamide exposure and breast cancer risk overall and a positive association was observed with premenopausal cancer
- Restricted cubic spline analyses suggested evidence for nonlinearity of these associations, with higher HRs for intermediate (quartile 2) and high (quartile 4) exposures.
- Receptor-specific analyses revealed positive associations with estrogen receptor-positive breast cancer (total and premenopausal).
- Acrylamide intake was not associated with postmenopausal breast cancer.
Results from this large prospective cohort study suggest a positive association between dietary acrylamide and breast cancer risk, especially in premenopausal females, and provide new insights that support continued mitigation strategies to reduce the content of acrylamide in food.
Reference:
Alice Bellicha, et al. Dietary exposure to acrylamide and breast cancer risk: results from the NutriNet-Santé cohort. PMID: 36055962 DOI: 10.1093/ajcn/nqac167
Keywords:
Dietary, exposure, acrylamide, breast, cancer, risk, results, NutriNet-Santé, cohort, acrylamide; breast cancer risk; cohort; food processing; neo-formed contaminant, Alice Bellicha Gaëlle Wendeu-Foyet Xavier Coumoul Meriem Koual Fabrice Pierre Françoise Guéraud,Laurent Zelek, Charlotte Debras Bernard Srour Laury Sellem, Emmanuelle Kesse-Guyot, Chantal Julia, Pilar Galan Serge Hercberg, Mélanie Deschasaux-Tanguy, Mathilde Touvie, The American Journal of Clinical Nutrition
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751