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  • Spore-forming...

Spore-forming probiotics effective in treatment of functional dyspepsia: Lancet

Written By : Dr. Nandita Mohan |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-08-13T09:00:52+05:30  |  Updated On 23 March 2022 5:18 PM IST
Spore-forming probiotics effective in treatment of functional dyspepsia: Lancet
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Current treatments for functional dyspepsia have limited efficacy or present safety issues. However, B coagulans MY01 and B subtilis MY02, the spore forming probiotics were found to be efficacious and safe in the treatment of functional dyspepsia, reports a recent study published in the The Lancet Gastroenterology & Hepatology Journal.

Lucas Wauters and colleagues from the Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium aimed to assess spore-forming probiotics in functional dyspepsia as monotherapy or add-on therapy to long-term treatment with proton-pump inhibitors.

The authors carried out a single-centre, randomised, double-blind, placebo-controlled pilot trial. Adult patients (≥18 years) with functional dyspepsia were randomly assigned (1:1) via computer-generated blocked lists, stratified by proton-pump inhibitor status, to receive 8 weeks of treatment with probiotics (Bacillus coagulans MY01 and Bacillus subtilis MY02, 2·5 × 109 colony-forming units per capsule) or placebo consumed twice per day, followed by an open-label extension phase of 8 weeks.

Individuals with a history of abdominal surgery, diabetes, coeliac or inflammatory bowel disease, active psychiatric conditions, and use of immunosuppressant drugs, antibiotics, or probiotics in the past 3 months were excluded.

All patients and on-site study personnel were masked to treatment allocation in the first 8 weeks. Symptoms, immune activation, and faecal microbiota were assessed and recorded.

The primary endpoint was a decrease of at least 0·7 in the postprandial distress syndrome (PDS) score of the Leuven Postprandial Distress Scale in patients with a baseline PDS score of 1 or greater (at least mild symptoms), assessed in the intention-to-treat population.

A total of 68 patients with functional dyspepsia were included, out of which 51 [75%] were women with a mean age 40·1 years. The authors randomly assigned 32 participants to probiotics and 36 to placebo.

The proportion of clinical responders was higher with probiotics than placebo. The number of patients with adverse events was similar with probiotics and placebo. Two serious adverse events occurring during the open-label phase (appendicitis and syncope in two separate patients) were assessed as unlikely to be related to the study product.

This led the authors to conclude that in this exploratory study, B coagulans MY01 and B subtilis MY02 were efficacious and safe in the treatment of functional dyspepsia.

https://doi.org/10.1016/S2468-1253(21)00226-0



Spore-forming probioticseffectivetreatmentfunctional dyspepsiaThe Lancet Gastroenterology & Hepatology Journal
Source : The Lancet Gastroenterology & Hepatology Journal
Dr. Nandita Mohan
Dr. Nandita Mohan

    Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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