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Terlipressin effective in GE variceal bleeding and hepatorenal syndrome in liver cirrhosis
Recent Practice Guidance has supported the use of Terlipressin for gastroesophageal variceal bleeding and hepatorenal syndrome (HRS) in liver cirrhosis as per a study that was published in the journal Therapeutic Advances in Gastroenterology.
Liver cirrhosis has a high risk of morbidity and mortality and is a major global health burden worldwide. Lately, terlipressin has been prescribed for the management of liver cirrhosis–related complications. Hence researchers from the Chinese Society of Gastroenterology conducted a study to develop evidence-based clinical practice guidance on the use of terlipressin for liver cirrhosis–related complications. The clinical practice guidance based on a comprehensive literature review and experts' clinical experiences was formulated by the gastroenterologists, hepatologists, infectious disease specialists, surgeons, and clinical pharmacists invited by the Hepatobiliary Study Group of the Chinese Society of Gastroenterology of the Chinese Medical Association and Hepatology Committee of the Chinese Research Hospital Association.
Results:
- 10 major guidance statements regarding the efficacy and safety of terlipressin in liver cirrhosis were proposed.
- Terlipressin can be advantageous and hence recommended in the management of acute variceal bleeding and hepatorenal syndrome (HRS) in cirrhotic patients.
- It should be considered in acute gastrointestinal bleeding patients with liver cirrhosis before endoscopy and in cirrhotic patients with acute gastrointestinal bleeding and renal dysfunction.
- There is insufficient evidence regarding the use of terlipressin in cirrhotic patients with ascites, post-paracentesis circulatory dysfunction, bacterial infections, and those undergoing hepatic resection and liver transplantation.
- Terlipressin-related adverse events, mainly including gastrointestinal symptoms, electrolyte disturbance, and cardiovascular and respiratory adverse events, should be closely monitored.
Thus, the researchers put forth from their clinical practice guidance that terlipressin is beneficial for gastroesophageal variceal bleeding and HRS in liver cirrhosis but suggested high-quality studies to further clarify its potential effects in other liver cirrhosis–related complications.
For further reading, click here: 10.1177/17562848221098253
Qi X, Bai Z, Zhu Q, et al. Practice guidance for the use of terlipressin for liver cirrhosis-related complications. Therap Adv Gastroenterol. 2022;15:17562848221098253. Published 2022 May 18.
BDS, MDS
Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751