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Individuals with blood type O may have lowest risk of COVID-19, find studies
Two retrospective studies in Blood Advances have added to the growing evidence supporting an association between blood type and COVID-19 vulnerability, indicating that people with blood type O may be less susceptible to infection and experience milder disease. A Danish study compared data from around 473,000 COVID-19–positive individuals with a control group of 2.2 million...
Two retrospective studies in Blood Advances have added to the growing evidence supporting an association between blood type and COVID-19 vulnerability, indicating that people with blood type O may be less susceptible to infection and experience milder disease.
A Danish study compared data from around 473,000 COVID-19–positive individuals with a control group of 2.2 million people in the general population,
The results indicated fewer infected people with blood type O (risk ratio [RR], 0.87, 95% confidence interval [CI], 0.82 to 0.91, P < 0.001) and more people with A, B, and AB types. No associations were found between non-O blood groups and comorbidities that might explain infection rate differences.
The authors hypothesized that the presence of virus-neutralizing anti-A and anti-B antibodies on mucosal surfaces of some type O individuals may explain the relative protection for this blood type.
A second study of 95 critically ill COVID-19 patients in a Vancouver, Canada, hospital found that—after adjusting for sex, age, and comorbidities—patients with blood types A or AB were more likely to require mechanical ventilation than patients with types O or B (84% vs 61%, P = 0.02), indicating higher rates of lung damage.
Patients with blood types A and AB also had higher rates of dialysis for kidney failure, suggesting increased organ dysfunction or failure due to COVID-19 (32% vs 95%, P = 0.004). Patients with blood types A and AB did not have longer hospital stays than those with types O or B, but they did experience longer intensive care unit stays, which may signal greater COVID-19 severity.
"The unique part of our study is our focus on the severity effect of blood type on COVID-19. We observed this lung and kidney damage, and in future studies, we will want to tease out the effect of blood group and COVID-19 on other vital organs," said study author Mypinder S. Sekhon, MD, of the University of British Columbia in a news release yesterday.
"Of particular importance as we continue to traverse the pandemic, we now have a wide range of survivors who are exiting the acute part of COVID-19, but we need to explore mechanisms by which to risk stratify those with longer-term effects," he added.
Though these new studies add evidence that there may be an association between blood type and vulnerability to COVID-19; however, additional research is needed to better understand why and what it means for patients.
For the full article,follow the link: https://doi.org/10.1182/bloodadvances.2020002657
Dr Satabdi Saha (BDS, MDS) is a practicing pediatric dentist with a keen interest in new medical researches and updates. She has completed her BDS from North Bengal Dental College ,Darjeeling. Then she went on to secure an ALL INDIA NEET PG rank and completed her MDS from the first dental college in the country – Dr R. Ahmed Dental College and Hospital. She is currently attached to The Marwari Relief Society Hospital as a consultant along with private practice of 2 years. She has published scientific papers in national and international journals. Her strong passion of sharing knowledge with the medical fraternity has motivated her to be a part of Medical Dialogues.