Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Nephrology
  • Nephrology News
  • Allopurinol not tied...

Allopurinol not tied to mortality risk in patients with gout with CKD, study finds

Medical Dialogues Editorial TeamWritten by Medical Dialogues Editorial Team Published On 2022-02-04T09:00:00+05:30  |  Updated On 4 Feb 2022 3:30 AM GMT
Allopurinol not tied to mortality risk in patients with gout with CKD, study finds
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • koo
  • Email

China: A new study shows that neither the commencement of allopurinol, the achievement of the target serum urate (SU) level with allopurinol, nor the escalation of allopurinol dosage was related to increased mortality in patients with gout and concomitant chronic renal disease (CKD). This study was conducted by Jie Wei and the team, the results of which were published in Annals of...

China: A new study shows that neither the commencement of allopurinol, the achievement of the target serum urate (SU) level with allopurinol, nor the escalation of allopurinol dosage was related to increased mortality in patients with gout and concomitant chronic renal disease (CKD).

This study was conducted by Jie Wei and the team, the results of which were published in Annals of Internal Medicine.

Two recent randomized clinical studies of rising allopurinol dosages for the development of CKD found no benefits but a potentially increased risk of mortality. It is uncertain if the risk exists in people with gout and concomitant CKD. As a result, the goal of this study was to investigate the relationship between allopurinol commencement, allopurinol dosage escalation, and attaining target SU level after allopurinol initiation and all-cause mortality in patients with both gout and CKD.

This was a cohort study that looked into The Health Improvement Network U.K. primary care database (2000 to 2019). The participants of this study were patients of age 40 or older with gout and concurrent moderate-to-severe CKD. The researchers looked at the relationship between starting allopurinol and all-cause mortality during a 5-year period in propensity score (PS)–matched populations. The following hypothetical trials were analyzed for mortality throughout a 5-year follow-up period in allopurinol initiators: attaining goal SU level (0.36 mmol/L) versus not achieving target SU level, and dosage escalation against no dose escalation.

The key findings of this study were as follow:

1. Mortality rates in 5277 allopurinol initiators and 5277 PS-matched noninitiators were 4.9 and 5.8 per 100 person-years, respectively (hazard ratio [HR], 0.85).

2. In the target trial emulation analysis, the HR of mortality for the achieving target SU level group versus the not achieving target SU level group was 0.87; the HR of mortality for allopurinol in the dose-escalation group versus the no dose escalation group was 0.88; and the HR of mortality for allopurinol in the dose-escalation group versus the no dose.

In conclusion, this study's findings indicate that starting allopurinol, increasing its dose, or reaching target serum urate (SU) levels are not related to an increased risk of death in gout patients with chronic renal disease (CKD).

Reference:

Jie Wei, Hyon K. Choi, Tuhina Neogi, et al. Allopurinol Initiation and All-Cause Mortality Among Patients With Gout and Concurrent Chronic Kidney Disease: A Population-Based Cohort Study. Ann Intern Med. [Epub ahead of print 25 January 2022]. doi:10.7326/M21-2347


Annals of Internal MedicineChronic kidney diseaseAllopurinolgout
Source : Annals of Internal Medicine
Medical Dialogues Editorial Team
Medical Dialogues Editorial Team

    Medical Dialogues consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers. Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.

    Show Full Article
    Next Story
    Similar Posts
    NO DATA FOUND

    Editorial

    Journal Club Today

    Health News Today

    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    X