Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
    • Anesthesia
    • CTVS
    • Cardiology
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • Diet and nutrition
    • ENT
    • Gastroenterology
    • Health Dialogues
    • Health News today
    • Health Shorts
    • Health Updates
    • Health video of the day
    • Laboratory Medicine
    • Latest Videos
    • Latest Webinars
    • MD shorts
    • Medical News Today
    • Medical Updates
    • Medical Video of the day
    • Medicine
    • Medico Legal Update
    • Nephrology
    • Neurology and Neurosurgery
    • Obstetrics and Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics & Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Top Videos
    • Urology
Medical Dialogues
  • Medical News
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Medical Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
    • Pharmacy Education News
  • MDTV
      • Anesthesia
      • CTVS
      • Cardiology
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • Diet and nutrition
      • ENT
      • Gastroenterology
      • Health Dialogues
      • Health News today
      • Health Shorts
      • Health Updates
      • Health video of the day
      • Laboratory Medicine
      • Latest Videos
      • Latest Webinars
      • MD shorts
      • Medical News Today
      • Medical Updates
      • Medical Video of the day
      • Medicine
      • Medico Legal Update
      • Nephrology
      • Neurology and Neurosurgery
      • Obstetrics and Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics & Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Top Videos
      • Urology
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Medical Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
  • Case of the Day
  • Editorial
  • Home
  • Nephrology
  • Nephrology News
  • Metabolically Healthy...

Metabolically Healthy Obesity a misnomer- Overweight don't escape from incident CKD: Study

Dr Kartikeya KohliWritten by Dr Kartikeya Kohli Published On 2022-01-21T10:00:54+05:30  |  Updated On 2022-01-21T10:55:02+05:30
Metabolically Healthy Obesity a misnomer- Overweight dont escape from incident CKD: Study
  • Facebook
  • Twitter
  • Whatsapp
  • Telegram
  • Linkedin
  • Email
  • koo
  • Facebook
  • Twitter
  • Whatsapp
  • Telegram
  • Linkedin
  • Email
  • koo
  • Facebook
  • Twitter
  • Whatsapp
  • Telegram
  • Linkedin
  • Email
  • koo

The phrase "metabolically healthy obesity" (obesity without any metabolic abnormality) first entered the scientific lexicon in the early 2000s, when some observational data indicated insulin resistance was not a universal or inevitable finding among all persons with obesity. In a recent study, researchers have found that people living with 'healthy' obesity have a 66% higher risk of...

The phrase "metabolically healthy obesity" (obesity without any metabolic abnormality) first entered the scientific lexicon in the early 2000s, when some observational data indicated insulin resistance was not a universal or inevitable finding among all persons with obesity. In a recent study, researchers have found that people living with 'healthy' obesity have a 66% higher risk of developing chronic kidney disease (CKD) compared to metabolically healthy individuals with normal weight. The study findings were published in the American Journal of Kidney Disease on June 16, 2021.

Metabolically healthy obesity is not considered to be associated with an increased risk of morbidity and mortality. To further explore, Dr Krishnarajah Niratharakumar and his team conducted a study and assessed the association between metabolically healthy overweight/obesity and the risk of incident CKD in a British primary care population.

In a retrospective population-based cohort study, the researchers included around 4.5 million individuals from the UK's Health Improvement Network (THIN) database and tracked their health over an average of almost five-and-a-half years. Among 4.5 million individuals, 1,040,921 (23.4%) and 588,909 (13.2%) were metabolically healthy overweight and metabolically healthy obese, respectively.

They categorized 11 body size phenotypes defined by BMI categories (underweight, normal weight, overweight, and obesity) and 3 metabolic abnormalities (diabetes, hypertension, and dyslipidemia). The major outcome assessed was incident CKD defined as a recorded code for kidney replacement therapy, a recorded diagnosis of CKD, or by an estimated glomerular filtration rate of <60 mL/min/1.73 m2 for ≥90 days, or a urinary albumin-creatinine ratio >3 mg/mmol for ≥90 days.

Key findings of the study:

  • Upon comparing individuals with a metabolically healthy normal weight and healthy overweight/ Obesity, the researchers found a higher risk of incident CKD among those who had metabolically healthy overweight (adjusted HR, 1.30 ) and metabolically healthy obesity (adjusted HR, 1.66).
  • They noted that the association was stronger in those younger than 65 years of age.
  • In all BMI categories, they observed a greater risk of incident CKD with a greater number of metabolic abnormalities in a graded manner.

The authors concluded, "Overweight and obesity without metabolic abnormality are associated with a higher risk of incident CKD compared with those with normal body weight and no metabolic abnormality".

In an accompanying editorial, Dr Srinivasan Beddhu and his team wrote, "First, we should abandon the term "metabolically healthy obesity." We often see patients in our clinical practice who have reduced eGFR and/or albuminuria and no other risk factors for CKD except obesity. In all cases, we should counsel our patients regarding the hazards of overweight and obesity, as obesity is a risk, or a risk accelerator, for incident CKD. As nephrologists become increasingly focused on reducing cardiometabolic risk as well as the risk of progressive CKD, we should become more facile with dietary, medical, surgical, and other effective weight-loss strategies."

For further information:

DOI: https://doi.org/10.1053/j.ajkd.2021.05.008


Metabolic Healthy Obesity Chronic Kidney Disease THIN database Albuminuria body mass index (BMI) body size phenotype diabetes glomerular filtration rate (GFR) hyperlipidemia hypertension incident CKD metabolic status overweight kidney replacement therapy (KRT) American Journal of Kidney Disease 
Article Source :  American Journal of Kidney Disease
Dr Kartikeya Kohli
Dr Kartikeya Kohli

    Dr Kartikeya Kohli is an Internal Medicine Consultant at Sitaram Bhartia Hospital in Delhi with super speciality training in Nephrology. He has worked with various eminent hospitals like Indraprastha Apollo Hospital, Sir Gangaram Hospital. He holds an MBBS from Kasturba Medical College Manipal, DNB Internal Medicine, Post Graduate Diploma in Clinical Research and Business Development, Fellow DNB Nephrology, MRCP and ECFMG Certification. He has been closely associated with India Medical Association South Delhi Branch and Delhi Medical Association and has been organising continuing medical education programs on their behalf from time to time. Further he has been contributing medical articles for their newsletters as well. He is also associated with electronic media and TV for conduction and presentation of health programs. He has been associated with Medical Dialogues for last 3 years and contributing articles on regular basis.

    Show Full Article
    Next Story
    Similar Posts
    Substantial discrepancies found between estimated and measured GFR

    Substantial discrepancies found between estimated and measured GFR

    Total and free concentrations of Polymyxin B1 may predict Polymyxin B-induced nephrotoxicity: Study

    Total and free concentrations of Polymyxin B1 may predict Polymyxin B-induced nephrotoxicity: Study

    Invasive management of chronic coronary disease not tied to QoL benefit in patients with CKD

    Invasive management of chronic coronary disease not tied to QoL benefit in patients with CKD

    Gut microbes differ in men with prostate cancer and those with benign hypertrophy

    Gut microbes differ in men with prostate cancer and those with benign hypertrophy

    Vibrators have potential pelvic health benefits for women and should be prescribed: Study

    Vibrators have potential pelvic health benefits for women and should be prescribed: Study

    Dissolving implantable device relieves pain on demand and without use of drugs.

    Dissolving implantable device relieves pain on demand and without use of drugs.

    Early empagliflozin initiation induces diuresis in decompensated HF without worsening kidney function

    Early empagliflozin initiation induces diuresis in decompensated HF without worsening kidney...

    Granulocytes count may be mediator of high sodium intake and poor Renal and CV Outcomes

    Granulocytes count may be mediator of high sodium intake and poor Renal and CV Outcomes

    Adjustable continence balloons benefit continence patients after prostatectomy

    Adjustable continence balloons benefit continence patients after prostatectomy

    Warfarin safe and effective option for managing hemodialysis patients with AF

    Warfarin safe and effective option for managing hemodialysis patients with AF

    Early RAAS initiation beneficial for children with lupus nephritis: Study

    Early RAAS initiation beneficial for children with lupus nephritis: Study

    New Super-Pulsed Thulium Fiber Laser Improves outcomes in Pediatric Patients with Urinary Stones

    New Super-Pulsed Thulium Fiber Laser Improves outcomes in Pediatric Patients with Urinary Stones

    Vitamin D Supplementation May Offset Bone Loss Caused by canagliflozin

    Vitamin D Supplementation May Offset Bone Loss Caused by canagliflozin

    Editorial

    Propranolol and essential tremors: A critical review

    Propranolol and essential tremors: A critical review

    Safeguarding Mental Health of Doctors & How They Can Prevent a Burnout

    Safeguarding Mental Health of Doctors & How They Can Prevent a Burnout

    Analyzing the Role of Levofloxacin in Urinary Tract Infections-A review

    Analyzing the Role of Levofloxacin in Urinary Tract Infections-A review

    Management of Allergic Rhinitis during COVID-19 Pandemic

    Management of Allergic Rhinitis during COVID-19 Pandemic

    Role of Probiotics in recurrent bacterial vaginosis: A review

    Role of Probiotics in recurrent bacterial vaginosis: A review

    View All

    Journal Club Today

    AI to help health care staff correctly diagnose alcohol-associated hepatitis, acute cholangitis

    AI to help health care staff correctly diagnose alcohol-associated hepatitis, acute cholangitis

    View All

    Health News Today

    Health Bulletin 6/July/2022

    Health Bulletin 6/July/2022

    View All
    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok
    X
    X