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  • Early initiation of...

Early initiation of Low dose levodopa fails to arrest Parkinson's disease progression: Study

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-07-17T04:15:26+05:30  |  Updated On 18 July 2024 11:11 AM IST
Early initiation of Low dose levodopa fails to arrest Parkinsons disease progression: Study
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A new study by Henrieke Frequin and colleagues found no differences in the occurrence of motor problems or the course of the disease between individuals with early Parkinson's disease (PD) who started therapy with a low dosage of levodopa at different periods. The findings of this study were published in the journal of Movement Disorders.

The patients were randomized to receive levodopa/carbidopa 300/75 mg daily for 80 weeks (early start) or a placebo for 40 weeks, after which they were given levodopa/carbidopa 300/75 mg daily for 40 weeks (delayed start). This research conducted follow-up visits at 3 and 5 years after baseline. After excluding individuals who did not develop PD 5 years after baseline, this study compared the effect of starting levodopa 40 weeks sooner to placebo on PD progress over 5 years. Using linear regression, this research evaluated the between-group differences in terms of the overall Unified Parkinson's Disease Rating Scale score at three and five years. The study contrasted the levodopa equivalent daily dose, the prevalence of wearing off and the prevalence of dyskinesia.

A total of 321 patients in all completed the five-year visit. At 3 and 5 years, there was no difference in the overall Unified Parkinson's Disease Rating Scale between treatment groups based on the adjusted square root transformation.

At five years, dyskinesia was reported by 46 out of 160 patients in the early-start group and 62 out of 161 patients in the delayed-start group (P = 0.06). Also, there were no appreciable differences in the frequency of wearing off or the daily dosage of levodopa equivalent between the groups.

There was no discernible difference in the course of the disease or the frequency of levodopa-induced motor problems between individuals with early, non-disabling Parkinson's disease (PD) who started the therapy with a low dosage of levodopa 40 weeks sooner vs 40 weeks later throughout the course of the next 5 years.

Overall, these results support that levodopa therapy does not alter the disease course and imply that beginning the medication early does not increase the likelihood of side effects such dyskinesia or wearing off.

Source:

Frequin, H. L., Verschuur, C. V. M., Suwijn, S. R., Boel, J. A., Post, B., Bloem, B. R., van Hilten, J. J., van Laar, T., Tissingh, G., Munts, A. G., Dijk, J. M., Lang, A. E., Dijkgraaf, M. G. W., Hoogland, J., & de Bie, R. M. A. (2024). Long‐Term Follow‐Up of the LEAP Study: Early Versus Delayed Levodopa in Early Parkinson’s Disease. In Movement Disorders (Vol. 39, Issue 6, pp. 975–982). Wiley. https://doi.org/10.1002/mds.29796

Movement Disorders JournalParkinson
Source : Movement Disorders
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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