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  • Osmotic demyelination...

Osmotic demyelination syndrome a rare complication of hyponatremia

Written By : Dr. Mahalakshmi Sivashankaran |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-05-06T08:15:39+05:30  |  Updated On 6 May 2023 2:27 PM IST
Osmotic demyelination syndrome a rare complication of hyponatremia
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Canada: A new study published in NEJM: Evidence has found that rapid correction of serum sodium is a common occurrence in patients with hyponatremia, but osmotic demyelination syndrome (ODS) is rare.

Hyponatremia is a condition in which there is a low level of sodium in the blood. Osmotic demyelination syndrome (ODS) is a rare but potentially devastating neurologic complication of hyponatremia that can lead to severe disability or death. The objective of this study was to determine the percentage of patients who developed ODS after being brought to the hospital with hyponatremia.

The study included 22,858 participants and was conducted by researchers at five academic hospitals in Toronto, Canada, and included a large, contemporary, multicenter cohort of patients admitted to the hospital with hyponatremia. The participants included in the study were adults with serum sodium levels less than 130mmol/L.

The following key takeaways were revealed by the study:

1. The mean initial serum sodium was 125 mmol/l, 11.9% of patients had serum sodium from 110 to 119 mmol/l and 1.2% had serum sodium less than 110 mmol/l.

2. Rapid correction of serum sodium occurred in 3632 (17.7%) admissions.

3. Twelve patients developed ODS (0.05%)

4. Seven (58%) patients who developed ODS did not have rapid correction of serum sodium.

The study concludes that although rapid correction of serum sodium is common in patients with hyponatremia, Osmotic demyelination syndrome (ODS) is a rare complication.

“However, more studies with a higher number of patients with ODS are needed to better understand potential causal factors for ODS. This study is a valuable contribution to the understanding of hyponatremia and its potential complications.” added the researchers of the study.

Reference:

MacMillan T., Shin S., Topf J., Kwan J., Weinerman A., et al.; Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia; NEJM Evid 2023;2(4) VOL. 2 NO. 4; doi: 10.1056/EVIDoa2200215

sodium correctionhyponatremiaOsmotic demyelination syndromecomplicationsODSNEJM EvidenceNEJMNEJM study
Article Source :  NEJM: Evidence
Dr. Mahalakshmi Sivashankaran
Dr. Mahalakshmi Sivashankaran

    Dr. Mahalakshmi Sivashankaran joined Medical Dialogues as an Intern in 2023. She is a BDS graduate from Manipal College of Dental Sciences, Mangalore Batch 2022, and worked as a Junior Resident at VMMC & Safdarjung Hospital at the Department of Dental Surgery till January 2023. She has completed a Diploma in Executive Healthcare management from the Loyola Institute of Business Administration, developing skills in Healthcare Management and Administration. She covers several medical specialties including Dental, ENT, Diagnostics, Pharmacology, Neurology, and Cardiology.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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