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  • Intermittent fasting...

Intermittent fasting may help prevent breast cancer, finds study

Dr Kartikeya KohliWritten by Dr Kartikeya Kohli Published On 2021-02-04T14:30:02+05:30  |  Updated On 4 Feb 2021 8:57 AM GMT
Intermittent fasting may help prevent breast cancer, finds study
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Obesity and its associated metabolic deregulation is a strong risk factor for type 2 diabetes, heart, and kidney disease and importantly, at least 13 types of cancer including postmenopausal breast cancer, colorectal cancer, endometrial cancer, esophageal adenocarcinoma, and gallbladder cancer. In a recent preclinical study, researchers have found that time-restricted feeding (TRF) approach...

Obesity and its associated metabolic deregulation is a strong risk factor for type 2 diabetes, heart, and kidney disease and importantly, at least 13 types of cancer including postmenopausal breast cancer, colorectal cancer, endometrial cancer, esophageal adenocarcinoma, and gallbladder cancer. In a recent preclinical study, researchers have found that time-restricted feeding (TRF) approach on mouse models of obesity-driven postmenopausal breast cancer reduces tumour growth and breast cancer metastasis to the lung. They also found that TRF potentially reduces hyperinsulinemia. The study findings were published in the journal Nature Communications on January 25, 2021.

Recent studies have revealed that obesity and breast cancer are strongly associated. However, like other metabolic dysregulation, the mechanisms underlying the impact of obesity on breast cancer incidence, morbidity, mortality are not fully understood and studies to establish a mechanistic link are ongoing. Previous studies suggest weight loss in obese individuals by caloric restriction or fasting leads to beneficial effects on metabolism and on reducing cancer growth in both mice and humans. Time-restricted eating (TRE) is an attractive intervention to reduce insulin resistance and restore normal circadian rhythms, as it requires neither a change in diet nor physical activity. Based on the strength of data available in the literature, researchers of the USA conducted a study to test a time-restricted feeding (TRF) approach on mouse models of obesity-driven postmenopausal breast cancer.

In this study, researchers used mice and induced menopause either chemically or surgically. They gave two groups of mice unrestricted access to high-fat foods for 10 weeks before the trial began to make them obese. Another group of mice, the control group, was given normal chow throughout this period. During the study, one group of mice continued to have unrestricted access to high-fat foods, while the control group still had unrestricted access to normal chow. The final group of mice, who were fed on a TRF schedule, had access to high-fat foods only for 8 hours during the night as they are naturally most active during the night.

Key findings of the study were:

Upon analysis, researchers found that the TRF

  •                    Reduces breast cancer metastasis to the lung.
  •                    Increases whole-body insulin sensitivity.
  •                    Reduces hyperinsulinemia.
  •                    Restores diurnal gene expression rhythms in the tumor.
  •                    Attenuates tumor growth and insulin signaling.

The researchers claim these results are likely due to the fact that TRF improved circadian disruptions and metabolic problems associated with obesity.

They further mentioned "Importantly, inhibition of insulin secretion with diazoxide mimics TRF, whereas artificial elevation of insulin through insulin pumps implantation reverses the effect of TRF,"

The authors concluded, "Our data suggest that TRF is likely to be effective in breast cancer prevention and therapy."

For further information:

https://www.nature.com/articles/s41467-020-20743-7


time-restricted feedingbreast cancerpreclinical studyhyperinsulinemiadiurnal gene expression rhythmsnature communication
Article Source :  Nature Communications
Dr Kartikeya Kohli
Dr Kartikeya Kohli

    Dr Kartikeya Kohli is an Internal Medicine Consultant at Sitaram Bhartia Hospital in Delhi with super speciality training in Nephrology. He has worked with various eminent hospitals like Indraprastha Apollo Hospital, Sir Gangaram Hospital. He holds an MBBS from Kasturba Medical College Manipal, DNB Internal Medicine, Post Graduate Diploma in Clinical Research and Business Development, Fellow DNB Nephrology, MRCP and ECFMG Certification. He has been closely associated with India Medical Association South Delhi Branch and Delhi Medical Association and has been organising continuing medical education programs on their behalf from time to time. Further he has been contributing medical articles for their newsletters as well. He is also associated with electronic media and TV for conduction and presentation of health programs. He has been associated with Medical Dialogues for last 3 years and contributing articles on regular basis.

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