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  • Clinical outcomes of...

Clinical outcomes of chikungunya vary in kids if coinfected with scrub typhus: Study

Dr. Nandita MohanBy Dr. Nandita MohanPublished On 2021-06-11T09:00:56+05:30  |  Updated On 2021-06-11T09:01:22+05:30
Clinical outcomes of chikungunya vary in kids if coinfected with scrub typhus: Study

Recent research has found out that both the chikungunya and scrub typhus coinfection groups shared many similar clinical manifestations but in children, coinfection with scrub typhus often leads to modification of the clinical profile, complications, and chikungunya outcome.The study is published in the International Journal of Pediatrics.Chikungunya and scrub typhus infection are...

Recent research has found out that both the chikungunya and scrub typhus coinfection groups shared many similar clinical manifestations but in children, coinfection with scrub typhus often leads to modification of the clinical profile, complications, and chikungunya outcome.

The study is published in the International Journal of Pediatrics.

Chikungunya and scrub typhus infection are important causes of undifferentiated fever in tropical zones. The clinical manifestations in both conditions are nonspecific and often overlap.

Therefore, Santosh Pathak and colleagues from the Department of Pediatrics, Chitwan Medical College, Bharatpur, Nepal conducted the present study to compare the clinical manifestations and the outcome of chikungunya with chikungunya-scrub typhus coinfection in children.

A hospital-based observational study was conducted in children below 15 years of age over 16-month duration. Chikungunya was diagnosed by IgM ELISA. All positive chikungunya cases were subjected to scrub typhus testing, dengue testing, leptospira testing, and malaria testing. Clinical manifestations and outcomes of all patients were recorded.

The key findings highlighted were-

a. Out of the 382 admitted cases with fever, 11% () were diagnosed with chikungunya, and the majority (, 71.4%) were male.

b. Among the 42 chikungunya cases, 17 (40.5%) tested positive for scrub typhus and one positive for falciparum malaria.

c. Out of a total of 42 chikungunya cases, myalgia, nausea/vomiting, headache, abdominal pain, lymphadenopathy, hepatomegaly, splenomegaly, and edema were 81%, 73.8%, 66.7%, 64.3%, 59.5%, 52.4%, 40.5%, and 38.1%, respectively.

d. Besides, altered sensorium (31%), jaundice (26.2%), dry cough (21.4%), shortness of breath (19%), and seizures (16.7%) were other clinical manifestations present in this group of children.

e. Patients with chikungunya-scrub typhus coinfection reported headaches, pain in the abdomen, dry cough, shortness of breath, seizures, and splenomegaly, significantly more ( value < 0.05) compared to those with chikungunya only.

f. Thirteen (31%) children developed shock, five in the chikungunya group and eight in the chikungunya-scrub typhus coinfection group.

g. Six children in the coinfection group received inotrope.

h. Among the chikungunya-only cases, 22 recovered and one died, whereas in the chikungunya-scrub typhus coinfection group, fourteen recovered and three died.

Based on the findings, the authors concluded that "clinical manifestations, complications, and outcomes of chikungunya in children can vary when coinfected with scrub typhus. Therefore, a high index of suspicion is necessary to think of coinfection, mainly depending on the varied clinical presentation range."


Clinical manifestations complications outcomes chikungunya coinfected scrub typhus International Journal of Pediatrics 
Source : International Journal of Pediatrics
Dr. Nandita Mohan
Dr. Nandita Mohan

    Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped.

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