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  • Faropenem promising...

Faropenem promising antituberculosis candidate competing with ethambutol in efficacy

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-06-13T11:00:32+05:30  |  Updated On 13 Jun 2023 1:10 PM IST
Faropenem promising antituberculosis candidate competing with ethambutol in efficacy
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Faropenem rivals ethambutol in efficacy, with fewer side effects for First-line TB treatment suggests a new study published in the International Journal of Infectious Diseases

Faropenem has antituberculosis activity in vitro but its utility in treating patients with tuberculosis (TB) is unclear.

They conducted an open-label, randomized trial in China, involving newly diagnosed, drug-susceptible pulmonary TB. The control group was treated with the standard 6-month regimen. The experimental group replaced ethambutol with faropenem for 2 months. The primary outcome was the treatment success rate after 6 months of treatment. Noninferiority was confirmed if the lower limit of a 95% one-sided confidence interval (CI) of the difference was greater than −10%.

Results

A total of 227 patients eligible for the study were enrolled in the trial group and the control group in a ratio of 1:1. Baseline characteristics of participants were similar in both groups. In the modified intention-to-treat population, 88.18% of patients in the faropenem group achieved treatment success, and 85.98% of those in the control group were successfully treated, with a difference of 2.2% (95% CI, −6.73-11.13). In the per-protocol population, treatment success was 96.04% in the faropenem group and 95.83% in the control group, with a difference of 2.1% (95% CI, −5.31-5.72). The faropenem group showed noninferiority to the control group in the 6-month treatment success rates. The faropenem group had significantly fewer adverse events (P <0.01).

The study proved that oral faropenem regimen can be used for the treatment of TB, with fewer adverse events. (Chinese Clinical Trial Registry, ChiCTR1800015959).

Reference:

Yanwan Shangguan, Wanru Guo, Xuewen Feng, Ying Zhang, Lanjuan Li, Kaijin Xu. Randomized control study of the use of faropenem for treating patients with pulmonary tuberculosis. International Journal of Infectious Diseases. Published:April 15, 2023DOI:https://doi.org/10.1016/j.ijid.2023.04.388

Keywords:

Faropenem, rivals, ethambutol, efficacy, with, fewer, side, effects, First-line TB treatment, International Journal of Infectious Diseases, Yanwan Shangguan, Wanru Guo, Xuewen Feng, Ying Zhang, Lanjuan Li, Kaijin Xu.

FaropenemrivalsethambutolefficacywithfewersideeffectsFirst-line TB treatmentInternational Journal of Infectious Diseases
Source : International Journal of Infectious Diseases
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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