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  • Inhaled cortical...

Inhaled cortical steroids fraught with risk of adrenal suppression in long run

Hina ZahidWritten by Hina Zahid Published On 2022-03-22T18:45:21+05:30  |  Updated On 22 March 2022 1:19 PM GMT
Inhaled cortical steroids fraught with risk of adrenal suppression in long run
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Inhaled cortical steroids (ICS) can help patients manage asthma symptoms but concerns persist that ICS may reduce production of the steroid hormone cortisol in the body leading to adrenal suppression.Until now, studies of ICS and adrenal suppression have been limited and have produced conflicting findings. The researchers from Brigham and Women's Hospital and the University of...

Inhaled cortical steroids (ICS) can help patients manage asthma symptoms but concerns persist that ICS may reduce production of the steroid hormone cortisol in the body leading to adrenal suppression.Until now, studies of ICS and adrenal suppression have been limited and have produced conflicting findings.

The researchers from Brigham and Women's Hospital and the University of Cambridge conducted the largest metabolomic study of asthma to date. By analyzing the blood plasma of 14,000 individuals from four independent study cohorts, the team identified 17 steroid metabolites that were reduced in individuals with asthma and found that, even among patients taking low-dose ICS, ICS usage was associated with reduced cortisol levels. The researchers also found significant associations between adrenal insufficiency symptoms, including fatigue and anemia, in asthma patients taking ICS treatment compared to those who were not.

"The use of ICS has been instrumental in reducing asthma exacerbations and improving overall quality of life. However, while their effectiveness should not be understated, our findings suggest that the risks of ICS usage must also be considered," said co-senior author Jessica Lasky-Su, ScD, of the Channing Division of Network Medicine at the Brigham.

"Our work suggests that simple measures, such as regular cortisol monitoring and prescription of the lowest effective ICS dose, may help to mitigate the systemic side effects of ICS use," said co-senior author Claudia Langenberg, MD, PhD, of the MRC Epidemiology Unit at the University of Cambridge, UK, and Berlin Institute of Health at Charité Universitätsmedizin, Germany.

Adrenal suppression in patients with asthma treated with ICS might, therefore, represent a larger public health problem than previously recognized. Regular cortisol monitoring of patients with asthma treated with ICS is needed to provide the optimal balance between minimizing adverse effects of adrenal suppression while capitalizing on the established benefits of ICS treatment.

For further reference log on to:

https://www.nature.com/articles/s41591-022-01714-5


inhaled cortical steroidsasthma symptomsnature medicine
Source : Nature Medicine
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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