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Omalizumab beneficial in patients with moderate to severe allergic asthma regardless of BMI: Study
Impact of body mass index on omalizumab response in adults with moderate-to-severe allergic asthma by Bob Geng, et al. published in the Annals of Allergy, Asthma & Immunology.
Effectiveness of asthma treatment, including biologics, may be different in patients with higher body mass index (BMI).
Researchers examined response to omalizumab (dosed by serum immunoglobin E level and weight) by BMI category.
Pooled data from 2 randomized, double-blind, placebo-controlled studies of adults with moderate-to-severe allergic asthma were analyzed by BMI category (<25 kg/m 2 [normal/underweight], n = 397; 25 to <30 kg/m 2 [overweight], n = 330; ≥30 kg/m 2 [obese], n = 268). Placebo-adjusted exacerbation rate reductions were assessed by Poisson regression modeling. Changes from baseline in forced expiratory volume in 1 second (FEV 1), beclomethasone dipropionate (BDP) dose, Total Asthma Symptom Score (TASS), and Asthma Quality of Life Questionnaire (AQLQ) were assessed by analysis of covariance.
Results of the study are:
Greater placebo-adjusted exacerbation rate reductions (95% confidence interval) were observed with increasing BMI (normal/underweight, −37.4% [−69.0%, 26.8%]; overweight, −52.7% [−78.4%, 3.7%]; obese, −71.9% [−86.9%, −39.5%]). There were no differences in FEV 1 improvement between BMI categories at week 16 (normal/underweight, 76.2 [5.3-147.1] mL; overweight, 98.1 [13.9-182.4] mL; obese, 69.1 [−18.9, 157.2] mL). No differences in BDP dose reduction (µg) were noted between BMI categories (normal/underweight, 23.0 [15.7-30.3]; overweight, 22.5 [13.5-31.5]; obese, 16.6 [5.8-27.3]). Fewer patients in the higher BMI categories eliminated BDP use. There were trends for smaller improvements with higher BMI in TASS (normal/underweight, −0.52 [−0.82, −0.22]; overweight, −0.50 [−0.80, −0.20]; obese, −0.39 [−0.77, 0.00]) and AQLQ (normal/underweight, 0.34 [0.16-0.52]; overweight, 0.34 [0.13-0.55]; obese, 0.15 [−0.08, 0.39]).
Thus, the researchers concluded that Omalizumab provides benefit to patients with moderate-to-severe allergic asthma, regardless of BMI.
Reference:
Omalizumab benefits patients with moderate to severe allergic asthma regardless of BMI, according to a recent study published in the Annals of Allergy, Asthma & Immunology.
https://www.annallergy.org/article/S1081-1206%2822%2900045-X/fulltext
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751