- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Ragweed tablets improve asthma symptoms in kids with allergic rhinoconjunctivitis: Study
USA: Ragweed sublingual immunotherapy (SLIT) tablets leads to better asthma outcome scores in pediatric patients with allergic rhinoconjunctivitis, finds a recent study in the Journal of Allergy and Clinical Immunology. Treatment was well-tolerated in both the patients -- with and without asthma.
David Bernstein, Bernstein Allergy Group, Inc, Finneytown, Ohio, and colleagues evaluated the safety and efficacy of ragweed SLIT tablets in children with allergic rhinitis with or without conjunctivitis (AR/C) in this international, double-blind, placebo-controlled trial. Asthma outcomes were assessed as exploratory endpoints.
The study included 1025 children (aged 5-17 years; 42.7% had a history of asthma) with ragweed AR/C with or without asthma (FEV1 ≥80% predicted, excluded if high-dose ICS required). They were randomized in a ratio of 1:1 to receive either daily ragweed SLITtablets (12 Amb a 1-Unit dose) or placebo for up to 28 weeks.
Asthma outcomes consisted of the asthma daily symptom score (DSS). DSS was defined as the sum of cough, wheeze, chest tightness/ shortness of breath measured on a scale of 0-3 in the full analysis population (n5962) and the number of daily inhalations of as-needed short-acting beta-agonist (SABA) and number of weekly nocturnal awakenings due to asthma symptoms requiring SABA in subjects with asthma at baseline (n5406) during peak ragweed pollen season.
Asthma outcomes consisted of the asthma daily symptom score (DSS) defined as the sum of cough, wheeze, chest tightness/ shortness of breath measured on a scale of 0-3 in the full analysis population (n5962) and the number of daily inhalations of as-needed short-acting beta-agonist (SABA) and number of weekly nocturnal awakenings due to asthma symptoms requiring SABA in subjects with asthma at baseline (n5406) during peak ragweed pollen season.
Key findings of the study include:
- Relative improvement in asthma DSS with ragweed SLITtablets compared with placebo during peak season was 230.7%.
- SABA use and nocturnal awakenings were improved with ragweed SLITtablets compared with placebo by 268.1% and 275.1% respectively.
- No severe or serious asthma events were observed with ragweed SLIT-tablets.
"Ragweed SLIT-tablets in children with AR/C improved asthma control outcomes compared with placebo during peak season. Treatment was well tolerated in subjects with and without asthma," wrote the authors.
"Impact of Ragweed SLIT-Tablets on Asthma Outcomes in a Large Trial of Children with Allergic Rhinoconjunctivitis
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751