Frailty in old age associated with complications after cholecystectomy: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-06-21T09:00:36+05:30 | Updated On 23 Aug 2021 12:03 PM IST

USA: Frail patients undergoing cholecystectomy are at a higher risk of adverse postoperative outcomes, according to a recent study in the journal HPB.

Cholecystectomy is the surgical procedure for the removal of the gall bladder. It is commonly used for the treatment of symptomatic gallstones and other gallbladder conditions.

Frailty is a geriatric syndrome characterized by weight loss, weakness, and low activity that potentially affects postoperative outcomes. Considering this, David Uihwan Lee, Tufts Medical Center, Boston, MA, USA, and colleagues aimed to evaluate the relationship between clinical frailty and post-cholecystectomy outcomes using a national registry of hospitalized patients.

For this purpose, the researchers used the 2011-2017 National Inpatient Sample database to identify patients who underwent cholecystectomy. Using the Johns Hopkins ACG frailty definition, the patients were stratified into binary (frailty and no-frailty) and tripartite frailty (frailty, prefrailty, no-frailty) indicators. The controls were matched to study cohort using 1:1 propensity score-matching and postoperative outcomes were compared.

Also Read: Frailty, A vital Index to Predict Postoperative Complications After Skull Base Surgery

Key findings of the study include:

· Post-match, using the binary term, frail patients (n=40067) had higher rates of mortality (OR 2.07), length of stay, costs, and complications. In multivariate, frailty was associated with higher mortality (aOR 2.06).

· When using tripartite frailty term, prefrail (n=35595) and frail (n=4472) patients had higher mortality (prefrailty: OR 2.04; frailty: OR 2.49), length of stay, costs, and complications.

· In multivariate, prefrailty and frailty were associated with higher mortality (prefrailty: aOR 2.02; frailty: aOR 2.54).

"This study shows the presence of frailty (and prefrailty) is an independent risk factor of adverse postoperative outcomes in patients undergoing cholecystectomy," concluded the authors.

Also Read:No benefit of PC over emergency cholecystectomy in Acute cholecystitis: Study

Reference:

The study titled, "The impact of frailty on the postoperative outcomes of patients undergoing cholecystectomy: propensity score matched analysis of 2011-2017 US hospitals," is published in the journal HPB.

DOI: https://www.hpbonline.org/article/S1365-182X(21)00173-8/fulltext

journal HPBcholecystectomyfrailtypostoperative complications

Source : HPB

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751