3D structure of 'causative agent' of malaria constructed

One strategy used by the pathogen to amplify its spreading probability is the formation of rosette-shaped clusters of uninfected erythrocytes surrounding a malaria-infected red blood cell. Since the parasite in the central cell of the rosette can easily infect the surrounding cells, the rosette enhances the infection.

One of the key players in the formation of the rosette is the protein PfEMP1, Plasmodium falciparum erythrocyte membrane proteinp PfEMP1 sticks out of the infected red blood cell and deceives one of the first defenses against malaria called the IgM antibodies.

The technique used by OIST researchers allows them to have a unique dynamic view of the proteins' conformation.

Having this 3D structural model of the PfEMP1 and IgM complex can help scientists to design anti-malaria pharmacological treatments that can break down or wash out malaria rosettes without hurting the patient.