US scientists create insulin-producing pancreatic cells from human skin cells

In the study, the scientists first used pharmaceutical and genetic molecules to reprogramme skin cells into endoderm progenitor cells early developmental cells that have already been designated to mature into one of a number of different types of organs.

With this method, the cells don't have to be taken all the way back to pluripotent stem cell state, meaning the scientists can turn them into pancreatic cells faster. The researchers have used a similar procedure previously to create heart, brain, and liver cells.

After another four molecules were added, the endoderm cells divided rapidly, allowing more than a trillion-fold expansion. Critically, the cells did not display any evidence of tumour formation, and they maintained their identity as early organ-specific cells.

The scientists then progressed these endoderm cells two more steps, first into pancreatic precursor cells, and then into fully-functional pancreatic beta cells.

Most importantly, these cells protected mice from developing diabetes in a model of disease, having the critical ability to produce insulin in response to changes in glucose levels.

"This new cellular reprogramming and expansion paradigm is more sustainable and scalable than previous methods. Using this approach, cell production can be massively increased while maintaining quality control at multiple steps," said Sheng Ding, a senior investigator in the Roddenberry Stem Cell Centre at Gladstone and co-author of the study.