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  • Digoxin or bisoprolol...

Digoxin or bisoprolol did not improve quality of life in AF patients with HF: JAMA

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-01-04T21:00:30+05:30  |  Updated On 13 Oct 2023 4:39 PM IST
Digoxin or bisoprolol did not improve quality of life in AF patients with HF: JAMA
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England: Treatment with low-dose digoxin or bisoprolol in patients with permanent atrial fibrillation and heart failure symptoms did not make any significant difference in quality of life at 6 months, reveals a recent study in the journal JAMA.

There is not enough evidence to support selection of heart rate control therapy in patients having permanent atrial fibrillation, particularly in those with coexisting heart failure. Considering this, Dipak Kotecha, Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, England, and colleagues designed the Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF) trial. The trial was designed to compare patient-reported quality of life among patients with permanent AF and symptoms of heart failure treated with low-dose digoxin or bisoprolol for heart rate control.

The trial included 160 patients (aged 60 years and older) with permanent atrial fibrillation (defined as no plan to restore sinus rhythm) and dyspnea classified as New York Heart Association class II or higher. The patients were recruited from 3 hospitals and primary care practices in England from 2016 through 2018; last follow-up occurred in October 2019.

The patients were randomized to receive either digoxin (n = 80; dose range, 62.5-250 μg/d; mean dose, 161 μg/d) or bisoprolol (n = 80; dose range, 1.25-15 mg/d; mean dose, 3.2 mg/d). Among 160 patients 145 (91%) completed the trial and 150 (94%) were included in the analysis for the primary outcome.

The primary end point was patient-reported quality of life using the 36-Item Short Form Health Survey physical component summary score (SF-36 PCS) at 6 months (higher scores are better; range, 0-100), with a minimal clinically important difference of 0.5 SD.

Key findings of the study include:

  • There was no significant difference in the primary outcome of normalized SF-36 PCS at 6 months (mean, 31.9 for digoxin vs 29.7 for bisoprolol).
  • Of the 17 secondary outcomes at 6 months, there were no significant between-group differences for 16 outcomes, including resting heart rate (a mean of 76.9/min with digoxin vs a mean of 74.8/min with bisoprolol; difference, 1.5/min).
  • The modified EHRA class was significantly different between groups at 6 months; 53% of patients in the digoxin group reported a 2-class improvement vs 9% of patients in the bisoprolol group (adjusted odds ratio, 10.3).
  • At 12 months, 8 of 20 outcomes were significantly different (all favoring digoxin), with a median NT-proBNP level of 960 pg/mL in the digoxin group vs 1250 pg/mL in the bisoprolol group (ratio of geometric means, 0.77).
  • Adverse events were less common with digoxin; 20 patients (25%) in the digoxin group had at least 1 AE vs 51 patients (64%) in the bisoprolol group.
  • There were 29 treatment-related AEs and 16 serious AEs in the digoxin group vs 142 and 37, respectively, in the bisoprolol group.

"Among patients with permanent atrial fibrillation and symptoms of heart failure treated with low-dose digoxin or bisoprolol, there was no statistically significant difference in quality of life at 6 months, " wrote the authors.

"These findings support potentially basing decisions about treatment on other end points," they concluded.

"Effect of Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation on Patient-Reported Quality of Life: The RATE-AF Randomized Clinical Trial," is published in the journal JAMA.

DOI: https://jamanetwork.com/journals/jama/fullarticle/2774407

JAMAatrial fibrillationDigoxinbisoprololheart failure
Source : JAMA
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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