Severe hypoglycemia related to heart failure risk in type 2 diabetes patients: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-11-29T10:15:28+05:30 | Updated On 29 Nov 2021 11:46 AM IST

USA: Severe hypoglycemia is associated with a greater risk of heart failure, reveals a study of a large cohort of adults with type 2 diabetes. The study appears in the Journal of Clinical Endocrinology & Metabolism.

In the study, Justin B Echouffo-Tcheugui, Johns Hopkins School of Medicine, Baltimore, MD, USA, and colleagues evaluated the association of severe hypoglycemia with incident HF among individuals with type 2 diabetes. The association was investigated in participants of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study.

The researchers assessed severe hypoglycemia episodes during the initial 24 months following randomization and defined using 2 methods: (1) symptomatic, severe hypoglycemic event requiring medical assistance (first definition); or (2) requiring any assistance (second definition). They prospectively followed participants without HF at baseline and during the first 24 months of the study for HF hospitalization. Adjusted hazard ratios (HR) were generated for the association of severe hypoglycemia and incident HF.

The study revealed the following findings:

Among 9208 participants (mean age 63 years, 38% female, 62% White), 365 had ≥ 1 episode of severe hypoglycemic.
Over a median follow-up duration of 3 years, there were 249 incident HF events.
After multivariable adjustment for relevant confounders, participants with severe hypoglycemia requiring medical assistance had a 68% higher relative risk of incident HF (HR 1.68), as compared with individuals who never experienced any episode of hypoglycemia.
Severe hypoglycemia requiring any assistance was also associated with a 49% higher relative risk of HF (HR 1.49).

The authors concluded, "in a large cohort of adults with type 2 diabetes, severe hypoglycemia was independently associated with greater risk of incident HF."

Reference:

Justin B Echouffo-Tcheugui, Arnaud D Kaze, Gregg C Fonarow, Sam Dagogo-Jack, Severe Hypoglycemia and Incident Heart Failure Among Adults With Type 2 Diabetes, The Journal of Clinical Endocrinology & Metabolism, 2021;, dgab794, https://doi.org/10.1210/clinem/dgab794

hypoglycemiatype 2 diabetesheart failureJournal of Clinical Endocrinology & Metabolism

Source : Journal of Clinical Endocrinology & Metabolism

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751